An Oklahoma born in 2010 has the fifth lowest life-expectancy in the US and American Indians have the shortest, 7.3 years less than the US average. Cancer, diabetes, cardiovascular disease, arthritis, and autoimmunity are leading causes of disability and early mortality, serving as sources of major health disparities in Oklahoma and other IDeA-states. Along with these diseases, tobacco use, opioid abuse, and child health are also prominent health concerns. The primary mission of the Oklahoma Shared Clinical and Translational Resources (OSCTR) is to improve health by catalyzing clinical and translational research (CTR) in these top health priorities. To fulfill its mission, the OSCTR integrates health professionals, investigators, and scientific resources at 29 public, private, and tribal partners/affiliate partners statewide. Oklahoma is an ideal setting for these efforts due to these high rates of chronic diseases, and large rural and tribal populations where improved health outcomes may serve as models across IDeA states. CTR on tribal health priorities and health equity is fostered by strong relationships between OSCTR research institutions and tribal nations/health systems. OSCTR houses the only CAP-certified biorepository affiliated with an IDeA-CTR, and cutting-edge resources for data research and medical data warehouses. Oklahoma also has a growing cadre of junior investigators who are launching independent CTR careers (most with OSCTR assistance), with institutional leaders who are committed to CTR and improving Oklahomans health. Concurrent with these strengths, the OSCTR is leveraging new partnerships to move toward prevention. Although many early successes are evident, CTR sustainability in Oklahoma and its impact on public health are limited by ongoing needs for infrastructure support and by a need for further development of the nascent clinical research infrastructure. Therefore, to expand research into diseases with high prevalence in rural and tribal populations, the OSCTR is helping tribal health systems build CTR infrastructure and fostering interactions through the Tribal Engagement Unit. To launch independent CTR careers of junior investigators from multiple disciplines, the OSCTR provides training, mentoring, pilot grants, and infrastructure. This includes patient registries, repositories, and data warehouses; recruiting and regulatory support; biostatistical and epidemiologic expertise; and comprehensive online resources linking investigators to relevant Core facilities at each OSCTR partner institution and Oklahoma IDeA program. To engage health professionals, communities, and patients in high-priority CTR, the OSCTR will develop an expanded online portal to educate patients and providers on CTR, and leverages a large network of community-oriented health improvement organizations. Finally, to develop and share effective infrastructure, the OSCTR collaborates with biomedical IDeA programs in Oklahoma and other states. Together, these activities will help develop a critical mass of investigators to sustain Oklahoma?s CTR infrastructure with a combination of federal funding, industry-sponsored clinical trials, and local support.

Public Health Relevance

The major causes of death and disability in the US have an even greater impact in Oklahoma, particularly for rural and minority citizens. To reduce the impact of these diseases on individuals and communities, we need to make new discoveries and move them into clinical practice. Therefore, this project unites researchers, health professionals, community partners, and scientific resources focused on top health priorities and health disparities: cancer and tobacco use, diabetes and obesity, cardiovascular disease, arthritis and autoimmunity, opioid abuse, and child health.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
2U54GM104938-06
Application #
9574012
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Gao, Hongwei
Project Start
2013-09-01
Project End
2023-06-30
Budget Start
2018-08-03
Budget End
2019-06-30
Support Year
6
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Oklahoma Health Sciences Center
Department
Type
Schools of Medicine
DUNS #
878648294
City
Oklahoma City
State
OK
Country
United States
Zip Code
73104
Jones, Daniel F; Hodgden, Jeffrey D; Onarecker, Cheyn D (2018) In adults with osteoarthritis of the knee, is conservative management more effective than intra-articular corticosteroid injections in relieving pain? J Okla State Med Assoc 111:712-713
Carroll, Dana Mowls; Brame, Lacy S; Stephens, Lancer D et al. (2018) Community-Based Study Recruitment of American Indian Cigarette Smokers and Electronic Cigarette Users. J Community Health 43:186-192
Hutchinson, Melanie; Hodgden, Jeffrey Dean (2018) Clinical Question: In women with preterm labor, do repeated courses of prenatal corticosteroids improve neonatal outcomes compared to a single course? J Okla State Med Assoc 111:498-499
Fulop, Gabor A; Kiss, Tamas; Tarantini, Stefano et al. (2018) Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation. Geroscience 40:513-521
Jiao, Yang; Watts, Tanya; Xue, Jing et al. (2018) Sorafenib and docosahexaenoic acid act in synergy to suppress cancer cell viability: a role of heme oxygenase 1. BMC Cancer 18:1042
Stock, Amanda J; Kasus-Jacobi, Anne; Pereira, H Anne (2018) The role of neutrophil granule proteins in neuroinflammation and Alzheimer's disease. J Neuroinflammation 15:240
Basu, Arpita; Kurien, Biji T; Tran, Huyen et al. (2018) Strawberries decrease circulating levels of tumor necrosis factor and lipid peroxides in obese adults with knee osteoarthritis. Food Funct 9:6218-6226
Hanscombe, Ken B; Morris, David L; Noble, Janelle A et al. (2018) Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans. Hum Mol Genet 27:3813-3824
Mannel, Rebecca; Peck, Jennifer D (2018) Outcomes Associated With Type of Milk Supplementation Among Late Preterm Infants. J Obstet Gynecol Neonatal Nurs 47:571-582
Bagavant, Harini; Dunkleberger, Micah L; Wolska, Nina et al. (2018) Antibodies to periodontogenic bacteria are associated with higher disease activity in lupus patients. Clin Exp Rheumatol :

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