An Oklahoma born in 2010 has the fifth lowest life-expectancy in the US and American Indians have the shortest, 7.3 years less than the US average. Cancer, diabetes, cardiovascular disease, arthritis, and autoimmunity are leading causes of disability and early mortality, serving as sources of major health disparities in Oklahoma and other IDeA-states. Along with these diseases, tobacco use, opioid abuse, and child health are also prominent health concerns. The primary mission of the Oklahoma Shared Clinical and Translational Resources (OSCTR) is to improve health by catalyzing clinical and translational research (CTR) in these top health priorities. To fulfill its mission, the OSCTR integrates health professionals, investigators, and scientific resources at 29 public, private, and tribal partners/affiliate partners statewide. Oklahoma is an ideal setting for these efforts due to these high rates of chronic diseases, and large rural and tribal populations where improved health outcomes may serve as models across IDeA states. CTR on tribal health priorities and health equity is fostered by strong relationships between OSCTR research institutions and tribal nations/health systems. OSCTR houses the only CAP-certified biorepository affiliated with an IDeA-CTR, and cutting-edge resources for data research and medical data warehouses. Oklahoma also has a growing cadre of junior investigators who are launching independent CTR careers (most with OSCTR assistance), with institutional leaders who are committed to CTR and improving Oklahomans health. Concurrent with these strengths, the OSCTR is leveraging new partnerships to move toward prevention. Although many early successes are evident, CTR sustainability in Oklahoma and its impact on public health are limited by ongoing needs for infrastructure support and by a need for further development of the nascent clinical research infrastructure. Therefore, to expand research into diseases with high prevalence in rural and tribal populations, the OSCTR is helping tribal health systems build CTR infrastructure and fostering interactions through the Tribal Engagement Unit. To launch independent CTR careers of junior investigators from multiple disciplines, the OSCTR provides training, mentoring, pilot grants, and infrastructure. This includes patient registries, repositories, and data warehouses; recruiting and regulatory support; biostatistical and epidemiologic expertise; and comprehensive online resources linking investigators to relevant Core facilities at each OSCTR partner institution and Oklahoma IDeA program. To engage health professionals, communities, and patients in high-priority CTR, the OSCTR will develop an expanded online portal to educate patients and providers on CTR, and leverages a large network of community-oriented health improvement organizations. Finally, to develop and share effective infrastructure, the OSCTR collaborates with biomedical IDeA programs in Oklahoma and other states. Together, these activities will help develop a critical mass of investigators to sustain Oklahoma?s CTR infrastructure with a combination of federal funding, industry-sponsored clinical trials, and local support.

Public Health Relevance

The major causes of death and disability in the US have an even greater impact in Oklahoma, particularly for rural and minority citizens. To reduce the impact of these diseases on individuals and communities, we need to make new discoveries and move them into clinical practice. Therefore, this project unites researchers, health professionals, community partners, and scientific resources focused on top health priorities and health disparities: cancer and tobacco use, diabetes and obesity, cardiovascular disease, arthritis and autoimmunity, opioid abuse, and child health.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
2U54GM104938-06
Application #
9574012
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Gao, Hongwei
Project Start
2013-09-01
Project End
2023-06-30
Budget Start
2018-08-03
Budget End
2019-06-30
Support Year
6
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Oklahoma Health Sciences Center
Department
Type
Schools of Medicine
DUNS #
878648294
City
Oklahoma City
State
OK
Country
United States
Zip Code
73104
Tarantini, Stefano; Yabluchanksiy, Andriy; Fülöp, Gábor A et al. (2017) Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice. Geroscience 39:601-614
Hollrah, David; Dawson, Kristin; Kennedye, Patrick et al. (2017) Question: In patients with type 2 diabetes, does diet soda consumption contribute to decline in blood sugar control? J Okla State Med Assoc 110:206-7
Langefeld, Carl D; Ainsworth, Hannah C; Cunninghame Graham, Deborah S et al. (2017) Transancestral mapping and genetic load in systemic lupus erythematosus. Nat Commun 8:16021
Hamm, Robert M; Yang, Huiqin (2017) Alternative Lens Model Equations for Dichotomous Judgments about Dichotomous Criteria. J Behav Decis Mak 30:527-532
Munroe, Melissa E; Young, Kendra A; Kamen, Diane L et al. (2017) Discerning Risk of Disease Transition in Relatives of Systemic Lupus Erythematosus Patients Utilizing Soluble Mediators and Clinical Features. Arthritis Rheumatol 69:630-642
Talsania, Mitali; Scofield, Robert Hal (2017) Menopause and Rheumatic Disease. Rheum Dis Clin North Am 43:287-302
Stavrakis, Stavros; Stoner, Julie A; Kardokus, Joel et al. (2017) Intermittent vs. Continuous Anticoagulation theRapy in patiEnts with Atrial Fibrillation (iCARE-AF): a randomized pilot study. J Interv Card Electrophysiol 48:51-60
Wagener, Theodore L; Floyd, Evan L; Stepanov, Irina et al. (2017) Have combustible cigarettes met their match? The nicotine delivery profiles and harmful constituent exposures of second-generation and third-generation electronic cigarette users. Tob Control 26:e23-e28
Csiszar, Anna; Tarantini, Stefano; Fülöp, Gábor A et al. (2017) Hypertension impairs neurovascular coupling and promotes microvascular injury: role in exacerbation of Alzheimer's disease. Geroscience :
Achilefu, Allison; Joshi, Kunal; Meier, Megan et al. (2017) Yoga and other meditative movement therapies to reduce chronic pain. J Okla State Med Assoc 110:14-16

Showing the most recent 10 out of 206 publications