The goal of the West Virginia Clinical and Translation Science Institute's (WVCTSI) IDeA-CTR application is to expand our infrastructure for, and practice of, clinical and translational research to a level competitive for a Clinical and Translational Science Award (CTSA). To this end, the WVCTSI was established in 2008 as the organizational home supporting research to address the health and healthcare needs of the people of West Virginia and Central Appalachia, and ultimately to eliminate health disparities. To realize our ambitious goal, the WVCTSI, which includes West Virginia University, Charleston Area Medical Center, West Virginia School of Osteopathic Medicine, and West Virginia United Health Systems, has partnered with the Appalachian Translational Research Institute, which was founded by our IDeA state partner and CTSA recipient the University of Kentucky. The WVCTSI will achieve its goal through pursuit of three aims: 1) Grow the WVCTSI as an academic home and a catalyst for clinical and translational research that targets cancer, cardiovascular-stroke, and obesity related diseases;2) Establish cross cutting research partnerships among the WVCTSI partnered institutions and collaborating CTSAs at University of Kentucky, Ohio State University, and Indiana University to increase our research capacity;and 3) Utilize innovative recruitment, training, and mentoring strategies to develop clinical and translational scientists at each of the WVCTSI institutions.
These aims are addressed through recruitment and support of clinical and translational scientists and a broad educational and mentoring program. In addition, participating faculty are provided with research resources that include biostatistics, clinical informatics, and access to a range of pilot funding mechanisms. Furthermore, mechanisms to streamline regulatory processes without compromising human subject protections and to engage communities fully in the research agenda are being developed. Finally, to ensure accountability and quality improvement, a robust evaluation program has been established. Overall, the WVCTSI has developed a strong infrastructure to increase the number of extramural funded clinical and translational researchers and has a well-considered plan for enhancing capacity and productivity over the next five years, positioning us for competitiveness for a CTSA.

Public Health Relevance

West Virginia suffers from numerous health disparities, notably for cancer, cardiovascular-stroke, and obesity related diseases. The WVCTSI, which includes health sciences and clinical institutions in the state and throughout central Appalachia, provides a means for the IDeA-CTR to enhance clinical and translational research and supporting infrastructure. This will result in long-term improvements to health healthcare through translation of research findings to clinical care and public health policy.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54GM104942-01
Application #
8339639
Study Section
Special Emphasis Panel (ZRR1-RI-3 (01))
Program Officer
Gorospe, Rafael
Project Start
2012-08-15
Project End
2017-06-30
Budget Start
2012-08-15
Budget End
2017-06-30
Support Year
1
Fiscal Year
2012
Total Cost
$19,581,898
Indirect Cost
$5,716,014
Name
West Virginia University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
191510239
City
Morgantown
State
WV
Country
United States
Zip Code
26506
Raval, Amit D; Madhavan, Suresh; Mattes, Malcolm D et al. (2016) Impact of Prostate Cancer Diagnosis on Noncancer Hospitalizations Among Elderly Medicare Beneficiaries With Incident Prostate Cancer. J Natl Compr Canc Netw 14:186-94
Engler-Chiurazzi, E B; Singh, M; Simpkins, J W (2016) From the 90's to now: A brief historical perspective on more than two decades of estrogen neuroprotection. Brain Res 1633:96-100
Wiener, R Constance; Vohra, Rini; Sambamoorthi, Usha et al. (2016) Caregiver Burdens and Preventive Dental Care for Children with Autism Spectrum Disorder, Developmental Disability and/or Mental Health Conditions: National Survey of CSHCN, 2009-2010. Matern Child Health J 20:2573-2580
Aliaga, Sofia; Zhang, Jun; Long, D Leann et al. (2016) Center Variation in the Delivery of Indicated Late Preterm Births. Am J Perinatol 33:1008-16
Labazi, Hicham; Teng, Bunyen; Zhou, Zhichao et al. (2016) Enhanced A2A adenosine receptor-mediated increase in coronary flow in type I diabetic mice. J Mol Cell Cardiol 90:30-7
DeVallance, E; Fournier, S; Lemaster, K et al. (2016) The effects of resistance exercise training on arterial stiffness in metabolic syndrome. Eur J Appl Physiol 116:899-910
Wiener, R Constance; Shen, Chan; Sambamoorthi, Nethra et al. (2016) Preventive dental care in older adults with diabetes. J Am Dent Assoc 147:797-802
Wimsatt, Jeffrey; Villers, Meghan; Thomas, Laurel et al. (2016) Oral perfluorooctane sulfonate (PFOS) lessens tumor development in the APC(min) mouse model of spontaneous familial adenomatous polyposis. BMC Cancer 16:942
Strong, Randy; Miller, Richard A; Antebi, Adam et al. (2016) Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer. Aging Cell 15:872-84
Wen, Sijin; Huang, Xuelin; Frankowski, Ralph F et al. (2016) A Bayesian multivariate joint frailty model for disease recurrences and survival. Stat Med 35:4794-4812

Showing the most recent 10 out of 493 publications