The goal of the West Virginia Clinical and Translation Science Institute's (WVCTSI) IDeA-CTR application is to expand our infrastructure for, and practice of, clinical and translational research to a level competitive for a Clinical and Translational Science Award (CTSA). To this end, the WVCTSI was established in 2008 as the organizational home supporting research to address the health and healthcare needs of the people of West Virginia and Central Appalachia, and ultimately to eliminate health disparities. To realize our ambitious goal, the WVCTSI, which includes West Virginia University, Charleston Area Medical Center, West Virginia School of Osteopathic Medicine, and West Virginia United Health Systems, has partnered with the Appalachian Translational Research Institute, which was founded by our IDeA state partner and CTSA recipient the University of Kentucky. The WVCTSI will achieve its goal through pursuit of three aims: 1) Grow the WVCTSI as an academic home and a catalyst for clinical and translational research that targets cancer, cardiovascular-stroke, and obesity related diseases;2) Establish cross cutting research partnerships among the WVCTSI partnered institutions and collaborating CTSAs at University of Kentucky, Ohio State University, and Indiana University to increase our research capacity;and 3) Utilize innovative recruitment, training, and mentoring strategies to develop clinical and translational scientists at each of the WVCTSI institutions.
These aims are addressed through recruitment and support of clinical and translational scientists and a broad educational and mentoring program. In addition, participating faculty are provided with research resources that include biostatistics, clinical informatics, and access to a range of pilot funding mechanisms. Furthermore, mechanisms to streamline regulatory processes without compromising human subject protections and to engage communities fully in the research agenda are being developed. Finally, to ensure accountability and quality improvement, a robust evaluation program has been established. Overall, the WVCTSI has developed a strong infrastructure to increase the number of extramural funded clinical and translational researchers and has a well-considered plan for enhancing capacity and productivity over the next five years, positioning us for competitiveness for a CTSA.

Public Health Relevance

West Virginia suffers from numerous health disparities, notably for cancer, cardiovascular-stroke, and obesity related diseases. The WVCTSI, which includes health sciences and clinical institutions in the state and throughout central Appalachia, provides a means for the IDeA-CTR to enhance clinical and translational research and supporting infrastructure. This will result in long-term improvements to health healthcare through translation of research findings to clinical care and public health policy.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54GM104942-01
Application #
8339639
Study Section
Special Emphasis Panel (ZRR1-RI-3 (01))
Program Officer
Gorospe, Rafael
Project Start
2012-08-15
Project End
2017-06-30
Budget Start
2012-08-15
Budget End
2017-06-30
Support Year
1
Fiscal Year
2012
Total Cost
$19,581,898
Indirect Cost
$5,716,014
Name
West Virginia University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
191510239
City
Morgantown
State
WV
Country
United States
Zip Code
26506
Fournier, Sara B; Donley, David A; Bonner, Daniel E et al. (2015) Improved arterial-ventricular coupling in metabolic syndrome after exercise training: a pilot study. Med Sci Sports Exerc 47:11-Feb
Adkins, Chris E; Nounou, Mohamed I; Mittapalli, Rajendar K et al. (2015) A novel preclinical method to quantitatively evaluate early-stage metastatic events at the murine blood-brain barrier. Cancer Prev Res (Phila) 8:68-76
Hunsberger, Holly C; Rudy, Carolyn C; Batten, Seth R et al. (2015) P301L tau expression affects glutamate release and clearance in the hippocampal trisynaptic pathway. J Neurochem 132:169-82
Thapa, Dharendra; Nichols, Cody E; Lewis, Sara E et al. (2015) Transgenic overexpression of mitofilin attenuates diabetes mellitus-associated cardiac and mitochondria dysfunction. J Mol Cell Cardiol 79:212-23
Wiener, R Constance; Long, D Leann; Jurevic, Richard J (2015) Blood levels of the heavy metal, lead, and caries in children aged 24-72 months: NHANES III. Caries Res 49:26-33
Jajosky, Audrey N; Coad, James E; Vos, Jeffrey A et al. (2014) RepSox slows decay of CD34+ acute myeloid leukemia cells and decreases T cell immunoglobulin mucin-3 expression. Stem Cells Transl Med 3:836-48
Croston, Tara L; Thapa, Dharendra; Holden, Anthony A et al. (2014) Functional deficiencies of subsarcolemmal mitochondria in the type 2 diabetic human heart. Am J Physiol Heart Circ Physiol 307:H54-65
Fournier, Sara B; Reger, Brian L; Donley, David A et al. (2014) Exercise reveals impairments in left ventricular systolic function in patients with metabolic syndrome. Exp Physiol 99:149-63
Luanpitpong, Sudjit; Chen, Michael; Knuckles, Travis et al. (2014) Appalachian mountaintop mining particulate matter induces neoplastic transformation of human bronchial epithelial cells and promotes tumor formation. Environ Sci Technol 48:12912-9
Kelley, George A; Kelley, Kristi S (2014) Effects of exercise on depressive symptoms in adults with arthritis and other rheumatic disease: a systematic review of meta-analyses. BMC Musculoskelet Disord 15:121

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