This is a proposal for a multi-institutional MIDAS Center of Excellence called the Center for Statistics and Quantitative Infectious Diseases (CSQUID). The mission the Center is to provide national and international leadership. The lead institution is the Fred Hutchinson Cancer Research Center (FHCRC). Other participating institutions are the University of Florida, Northeastern University, University of Michigan, Emory University, University of Washington (UW), University of Georgia, and Duke University. The proposal includes four synergistic research projects (RP) that will develop cutting-edge methodologies applied to solving epidemiologic, immunologic and evolutionary problems important for public health policy in influenza, dengue, polio, TB, and other infectious agents: RP1: Modeling, Spatial, Statistics (Lead: I. Longini, U. Florida);RP2: Dynamic Inference (Lead: P. Rohani, U Michigan);RP 3: Understanding transmission with integrated genetic and epidemiologic inference (Co-Leads: E. Kenah, U Florida and T. Bedford, FHCRC);RP 4: Dynamics and Evolution of Influenza Strain Variation (Lead: R. Antia, Emory U). The Software Development and Core Facilities (Lead: A. Vespignani, Northeastern U) will provide leadership in software development, access, and communication. The Policy Studies (Lead: J. Koopman, U Michigan) will provide leadership in communication of our research results to policy makers, as well as conducting novel research into policy making. The Training, Outreach, and Diversity Plans include ongoing training of 9 postdoctoral fellows and 5.25 predoctoral research assistants each year, support for participants in the Summer Institute for Statistics and Modeling in Infectious Diseases (UW) and ongoing Research Experience for Undergraduates programs at two institutions, among others. All participating institutions and the Center are committed to increasing diversity at all levels. Center-wide activities include Career Development Awards for junior faculty, annual workshops and symposia, outside speakers, and participation in the MIDAS Network meetings. Scientific leadership will be provided by the Center Director, a Leadership Committee, an external Scientific Advisory Board as well as the MIDAS Steering Committee.

Public Health Relevance

This multi-institutional MIDAS Center of Excellence provides a multi-disciplinary approach to computational, statistical, and mathematical modeling of important infectious diseases. The research is motivated by multiscale problems such as immunologic, epidemiologic, and environmental drivers of the spread of infectious diseases with the goal of understanding and communicating the implications for public health policy.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54GM111274-01
Application #
8753460
Study Section
Special Emphasis Panel (ZGM1-BBCB-5 (MI))
Program Officer
Sheeley, Douglas
Project Start
2014-09-12
Project End
2019-06-30
Budget Start
2014-09-12
Budget End
2015-06-30
Support Year
1
Fiscal Year
2014
Total Cost
$2,500,411
Indirect Cost
$659,637
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109
Dimitrov, Dobromir T; Troeger, Christopher; Halloran, M Elizabeth et al. (2014) Comparative effectiveness of different strategies of oral cholera vaccination in bangladesh: a modeling study. PLoS Negl Trop Dis 8:e3343