The Center for Reproductive Biology Research has served the scientific community for 35 years - first as a P30 Center, then over 10 years as a U54 SCCPIR Grant. The theme chosen and approved for the renewal application is """"""""Mechanisms Regulating Endometrial Function and Dysfunction and Impact on Ovarian Function"""""""". The Center's purpose is to establish a comprehensive research and training program to investigate the molecular mechanisms governing female reproduction in mice and humans. Research will be accomplished by four projects: Project I: """"""""Endometrial Steroid Receptor Coregulator-2 in Peri-implantation Biology"""""""" will investigate the role of nuclear receptor coregulators in endometrial function. Project II: """"""""Cellular Signals in Ovulation and Luteinization"""""""" will investigate the impact of endometrial inflammation on ovarian function. Project III: """"""""MicroRNAs in Endometrial Function and Dysfunction"""""""" will identify novel microRNAs altered in endometriosis and investigate their biology. Project IV: """"""""Role of the Orphan Nuclear Receptor COUPTF-II in Endometrial Biology"""""""" will determine mechanisms of nuclear receptor and growth factor regulation of endometrial function. Research projects are supported by 4 Cores: Administrative/Bioinformatics Core (A);Animal Core (B);Cell and Tissue Culture Core (C);and Integrated Microscopy Core (D). The Administrative Core will provide the Center with centralized management and centralized data analysis. The Animal Core will centralize the technology and resources required in the use of all in vivo models. The Cell Culture Core will provide investigators with specific reagents for the culture of primary cells and cell lines, as well as the expertise required to manipulate these cells. The Integrated Microscopy Core will aid investigators in the histological, immuno-histochemical and ultrastructural analysis required for the execution of their projects. Finally, the Center will support a Pilot Project to allow exploration of new areas of research, especially those that will translate findings to human clinical research. Thus, this Center for Reproductive Biology Research application will combine basic and translational research approaches to investigate the molecular mechanisms for regulation of female reproduction and fertility in animals and humans and foster the training of investigators in the field of reproductive biology.

Public Health Relevance

This Center grant application will investigate processes that control female reproduction and how these processes are disrupted in reproductive diseases. This research will aid in understanding the causes of female infertility and diseases of the reproductive tract.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HD007495-37
Application #
7809538
Study Section
Special Emphasis Panel (ZHD1-DSR-L (54))
Program Officer
De Paolo, Louis V
Project Start
1997-04-01
Project End
2014-03-31
Budget Start
2010-04-01
Budget End
2011-03-31
Support Year
37
Fiscal Year
2010
Total Cost
$1,539,873
Indirect Cost
Name
Baylor College of Medicine
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Szafran, Adam T; Stossi, Fabio; Mancini, Maureen G et al. (2017) Characterizing properties of non-estrogenic substituted bisphenol analogs using high throughput microscopy and image analysis. PLoS One 12:e0180141
Reineke, Lucas C; Tsai, Wei-Chih; Jain, Antrix et al. (2017) Casein Kinase 2 Is Linked to Stress Granule Dynamics through Phosphorylation of the Stress Granule Nucleating Protein G3BP1. Mol Cell Biol 37:
Tsai, Wei-Chih; Reineke, Lucas C; Jain, Antrix et al. (2017) Histone arginine demethylase JMJD6 is linked to stress granule assembly through demethylation of the stress granule nucleating protein G3BP1. J Biol Chem :
Piyarathna, Danthasinghe Waduge Badrajee; Rajendiran, Thekkelnaycke M; Putluri, Vasanta et al. (2017) Distinct Lipidomic Landscapes Associated with Clinical Stages of Urothelial Cancer of the Bladder. Eur Urol Focus :
Wang, Hai; Tian, Lin; Goldstein, Amit et al. (2017) Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies. Nat Commun 8:15045
Jin, Feng; Thaiparambil, Jose; Donepudi, Sri Ramya et al. (2017) Tobacco-Specific Carcinogens Induce Hypermethylation, DNA Adducts, and DNA Damage in Bladder Cancer. Cancer Prev Res (Phila) 10:588-597
Aagaard, Kjersti M; Lahon, Anismrita; Suter, Melissa A et al. (2017) Primary Human Placental Trophoblasts are Permissive for Zika Virus (ZIKV) Replication. Sci Rep 7:41389
Ha, Kyungsoo; Ma, Chengxian; Lin, Han et al. (2017) The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites. Nat Commun 8:15751
Roarty, K; Pfefferle, A D; Creighton, C J et al. (2017) Ror2-mediated alternative Wnt signaling regulates cell fate and adhesion during mammary tumor progression. Oncogene 36:5958-5968
Huq, Redwan; Samuel, Errol L G; Sikkema, William K A et al. (2016) Preferential uptake of antioxidant carbon nanoparticles by T lymphocytes for immunomodulation. Sci Rep 6:33808

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