The Nonhuman Primate (NHP) Reproductive Tissue Bank is maintained to provide male and female reproductive tract tissue from macaques to investigators with active or pending grants at NICHD. The tissue, shipping and handling costs are supported by NICHD/NIH through cooperative agreement U54 HD 18185 as part of the Specialized Centers Program in Reproduction Research (SCCPRR). The bank consists of a Revco -80C freezer, a computer, a dissecting microscope, a sterile hood, a lab assistant and the supervisor who monitor and collect tissue from necropsies and surgeries at the ONPRC. Samples collected, sample requests and samples mailed are tracked through a secure web-based database located on a server at NIH. The PI was instrumental in the design of the web site for the NHP Reproductive Tissue Bank. In addition, the web site is accessable to all SCCPRR investigators with Iogin capabilities for screening tissue availability and requesting tissue. The website is also linked to a supply of reproductive tract tissue from baboons located at the University of Chicago U54 Center (A. Fazleabas, PI). We have a large collection of frozen tissues at this time and we are collecting and fixing tissue prior to mailing upon the request of several investigators. Drs. Bethea and Stouffer also maintain collections of brain, pituitary and ovarian tissue, often collected after specific treatments or at specific stages, that are available on a collaborative basis.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DRG-D (29))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Oregon Health and Science University
United States
Zip Code
Lee, David M; Thomas, Carrie M; Xu, Fuhua et al. (2017) Subcutaneous ovarian tissue transplantation in nonhuman primates: duration of endocrine function and normalcy of subsequent offspring as demonstrated by reproductive competence, oocyte production, and telomere length. J Assist Reprod Genet 34:1427-1434
Lima, Fernanda B; Leite, Cristiane M; Bethea, Cynthia L et al. (2017) Progesterone increased ?-endorphin innervation of the locus coeruleus, but ovarian steroids had no effect on noradrenergic neurodegeneration. Brain Res 1663:1-8
Bethea, C L; Reddy, A P (2015) Ovarian steroids regulate gene expression related to DNA repair and neurodegenerative diseases in serotonin neurons of macaques. Mol Psychiatry 20:1565-78
McGee, W K; Bishop, C V; Pohl, C R et al. (2014) Effects of hyperandrogenemia and increased adiposity on reproductive and metabolic parameters in young adult female monkeys. Am J Physiol Endocrinol Metab 306:E1292-304
Xu, Jing; Xu, Min; Bernuci, Marcelo P et al. (2013) Primate follicular development and oocyte maturation in vitro. Adv Exp Med Biol 761:43-67
Peluffo, Marina C; Hennebold, Jon D; Stouffer, Richard L et al. (2013) Oocyte maturation and in vitro hormone production in small antral follicles (SAFs) isolated from rhesus monkeys. J Assist Reprod Genet 30:353-9
Telfer, Evelyn E; Zelinski, Mary B (2013) Ovarian follicle culture: advances and challenges for human and nonhuman primates. Fertil Steril 99:1523-33
Ting, A Y; Yeoman, R R; Campos, J R et al. (2013) Morphological and functional preservation of pre-antral follicles after vitrification of macaque ovarian tissue in a closed system. Hum Reprod 28:1267-79
Fisher, T E; Molskness, T A; Villeda, A et al. (2013) Vascular endothelial growth factor and angiopoietin production by primate follicles during culture is a function of growth rate, gonadotrophin exposure and oxygen milieu. Hum Reprod 28:3263-70
Stouffer, Richard L; Bishop, Cecily V; Bogan, Randy L et al. (2013) Endocrine and local control of the primate corpus luteum. Reprod Biol 13:259-71

Showing the most recent 10 out of 179 publications