The overall objective of this U54 Cooperative Specialized Research Center proposal is to characterize, at molecular and cellular levels, the hormonal pathways that regulate embryo implantation and fertility. Failure of the fertilized embryo to implant into the endometrium is a major cause of infertility. The Center will support a multidisciplinary group of scientists with a common interest to understand the mechanisms and cellular pathways that control implantation. The rationale for creating such a Center is to direct our concerted efforts toward the identification of endometrial factors whose aberrant expression or function leads to infertility. The achievement of this goal would require a cohesive, highly effective partnership between the basic and clinical scientists, addressing this question with innovative investigative strategies. This would advance our current understanding of the molecular basis of implantation and help identify factors that underlie infertility in women suffering from endometriosis, a common gynecologic disorder. The knowledge gained from these studies should also aid in developing new molecular diagnostic tools for screening endometrial dysfunction and enable targeted therapeutic strategies for the treatment of infertility. The program is comprised of four complementary, synergistic projects: (1) Role of C/EBP Deta in Uterine Decidualization and Implantation, (2) Nuclear Receptor Coregulators in Implantation and Uterine Function, (3) Regulation of Stromal Differentiation and Implantation by the BMP2 Pathway, and (4) Endometriosis as a Clinical Model of Predecidual Dysfunction. Investigators will be aided by two core facilities: Core A: Administrative Core, and Core B: Microscopy Core.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HD055787-05
Application #
8377601
Study Section
Special Emphasis Panel (ZHD1-DSR-L)
Project Start
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
5
Fiscal Year
2012
Total Cost
$99,875
Indirect Cost
$68,813
Name
University of Illinois Urbana-Champaign
Department
Type
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
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Kaya Okur, Hatice S; Das, Amrita; Taylor, Robert N et al. (2016) Roles of Estrogen Receptor-? and the Coactivator MED1 During Human Endometrial Decidualization. Mol Endocrinol 30:302-13
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Yu, Jie; Berga, Sarah L; Johnston-MacAnanny, Erika B et al. (2016) Endometrial Stromal Decidualization Responds Reversibly to Hormone Stimulation and Withdrawal. Endocrinology 157:2432-46
Li, Quanxi; Davila, Juanmahel; Kannan, Athilakshmi et al. (2016) Chronic Exposure to Bisphenol A Affects Uterine Function During Early Pregnancy in Mice. Endocrinology 157:1764-74
Guzzo, Mathilde; Agrebi, Rym; Espinosa, Leon et al. (2015) Evolution and Design Governing Signal Precision and Amplification in a Bacterial Chemosensory Pathway. PLoS Genet 11:e1005460
Davila, Juanmahel; Laws, Mary J; Kannan, Athilakshmi et al. (2015) Rac1 Regulates Endometrial Secretory Function to Control Placental Development. PLoS Genet 11:e1005458
Zhao, Yuechao; Gong, Ping; Chen, Yiru et al. (2015) Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis. Sci Transl Med 7:271ra9

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