Here we describe our administrative core and our Translational Pilot project, in response to the RFA. Our proposed U54 SCCPRIR Center is an integrated unit located in the Administrative Suite adjacent to Dr Reijo Pera's office in the Lorry Lokey Institute for Stem Cell Biology and Regenerative Medicine in the School (ISCBRM) of Medicine at Stanford University. The purpose of the Administrative Core is to coordinate functions for our U54 SCCPRIR Center by providing administrative and clerical support for the investigators and technical staff engaged in the Center's research and cores (Figure 1). The general organizational structure is as shown;support for administration is provided by Ms Joie Eckert and Dr Renee Reijo Pera;other personnel are supported on a cost-shared basis with the ISCBRM and the Department of Obstetrics and Gynecology. We note that day-to-day operations of the Administrative Core will involve coordinating the administrative aspects of the award which include: ? Accounting and record keeping, including preparation of requisitions for purchasing, services, supplies, and equipment, processing payment vouchers, and resolving problems between vendors; ? Providing monthly budget statements for each project and core; ? Tracking orders, expenditures, and payments throughout the university and outside suppliers; ? Scheduling quarterly SCCPRIR steering committee meetings and transcribing minutes of these meetings;co-organizing Reproductive Research Day with the Outreach and Education Core; ? Co-organizing and advertising the CRS workshop and journal club meetings for SCCPRIR members;coordinating manuscript and journal publication submissions; ? Compliance with health and safety, radiation safety, use of NIH approved human embryonic stem cell lines, and institutional review for human and animal subjects in medical research; ? Human resources and computer services; ? Coordinating the submission of non-competitive renewals for the U54 center projects and pilot projects and cooperative research initiative applications to the NIH SCCPRIR steering committee; ? Coordinating travel and reimbursements for travel for center director, co-director, and project and core directors, when appropriate, to the SCCPRIR annual research meeting SCCPRIR focus group meetings; ? Coordinate administration of the proposed Translational Pilot Project (see below;if funding is approved)

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DSR-L)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Stanford University
United States
Zip Code
Durruthy Durruthy, Jens; Ramathal, Cyril; Sukhwani, Meena et al. (2014) Fate of induced pluripotent stem cells following transplantation to murine seminiferous tubules. Hum Mol Genet 23:3071-84
Dominguez, Antonia A; Chiang, H Rosaria; Sukhwani, Meena et al. (2014) Human germ cell formation in xenotransplants of induced pluripotent stem cells carrying X chromosome aneuploidies. Sci Rep 4:6432
Ramathal, Cyril; Durruthy-Durruthy, Jens; Sukhwani, Meena et al. (2014) Fate of iPSCs derived from azoospermic and fertile men following xenotransplantation to murine seminiferous tubules. Cell Rep 7:1284-97
Durruthy-Durruthy, Jens; Briggs, Sharon F; Awe, Jason et al. (2014) Rapid and efficient conversion of integration-free human induced pluripotent stem cells to GMP-grade culture conditions. PLoS One 9:e94231
Reddy, Pradeep; Deguchi, Masashi; Cheng, Yuan et al. (2013) Actin cytoskeleton regulates Hippo signaling. PLoS One 8:e73763
Pera, Renee A Reijo (2013) Status of human germ cell differentiation from pluripotent stem cells. Reprod Fertil Dev 25:396-404
Medrano, Jose V; Pera, Renee A Reijo; Simon, Carlos (2013) Germ cell differentiation from pluripotent cells. Semin Reprod Med 31:14-23
Kawamura, Kazuhiro; Cheng, Yuan; Suzuki, Nao et al. (2013) Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment. Proc Natl Acad Sci U S A 110:17474-9
Hsueh, Aaron J; Rauch, Rami (2012) Ovarian Kaleidoscope database: ten years and beyond. Biol Reprod 86:192
Cheng, Yuan; Kawamura, Kazuhiro; Deguchi, Masashi et al. (2012) Intraovarian thrombin and activated protein C signaling system regulates steroidogenesis during the periovulatory period. Mol Endocrinol 26:331-40

Showing the most recent 10 out of 11 publications