Abstract

This study will extend existing data and ongoing research to understand the dynamics of childhood obesity in a large population of children living in 400 communities that vary on environmental risk regulators. Using a comprehensive electronic health record from a large primary care health system, we will use multilevel and system dynamic models to study the dynamics of obesity in over 55,000 children. We will also conduct a nested substudy of 1150 children from a subset of 80 communities to examine how features of the environment, as well as diet and physical activity alter gene expression as captured by locus-specific DNA methylation in what will be the largest study of its kind to date. We will also employ systems-dynamic models, motivated by real data, to simulate the epidemiologic consequences of policy interventions to up- or down regulate system components identified as determinants of obesity from earlier models.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HD070725-03
Application #
8481564
Study Section
Special Emphasis Panel (ZHD1-DSR-A)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
3
Fiscal Year
2014
Total Cost
$374,980
Indirect Cost
$92,020

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Perepezko, K; Tingey, L; Sato, P et al. (2018) Partnering with carryouts: implementation of a food environment intervention targeting youth obesity. Health Educ Res 33:4-13
Trude, Angela Cristina Bizzotto; Kharmats, Anna Yevgenyevna; Jones-Smith, Jessica C et al. (2018) Exposure to a multi-level multi-component childhood obesity prevention community-randomized controlled trial: patterns, determinants, and implications. Trials 19:287
Bartsch, Sarah M; Asti, Lindsey; Nyathi, Sindiso et al. (2018) Estimated Cost to a Restaurant of a Foodborne Illness Outbreak. Public Health Rep 133:274-286
Garcia, Mariana T; Sato, Priscila M; Trude, Angela C B et al. (2018) Factors Associated with Home Meal Preparation and Fast-Food Sources Use among Low-Income Urban African American Adults. Ecol Food Nutr 57:13-31
Ross, Alexandra; Krishnan, Nandita; Ruggiero, Cara et al. (2018) A mixed methods assessment of the barriers and readiness for meeting the SNAP depth of stock requirements in Baltimore's small food stores. Ecol Food Nutr 57:94-108
Carnell, S; Grillot, C; Ungredda, T et al. (2018) Morning and afternoon appetite and gut hormone responses to meal and stress challenges in obese individuals with and without binge eating disorder. Int J Obes (Lond) 42:841-849
Henry, JaWanna L; Trude, Angela C B; Surkan, Pamela J et al. (2018) Psychosocial Determinants of Food Acquisition and Preparation in Low-Income, Urban African American Households. Health Educ Behav 45:898-907
Min, Jungwon; Zhao, Yaling; Slivka, Lauren et al. (2018) Double burden of diseases worldwide: coexistence of undernutrition and overnutrition-related non-communicable chronic diseases. Obes Rev 19:49-61
Wang, Z; Xu, F; Ye, Q et al. (2018) Childhood obesity prevention through a community-based cluster randomized controlled physical activity intervention among schools in china: the health legacy project of the 2nd world summer youth olympic Games (YOG-Obesity study). Int J Obes (Lond) 42:625-633
Oddo, Vanessa M; Surkan, Pamela J; Hurley, Kristen M et al. (2018) Pathways of the association between maternal employment and weight status among women and children: Qualitative findings from Guatemala. Matern Child Nutr 14:

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