This study will extend existing data and ongoing research to understand the dynamics of childhood obesity in a large population of children living in 400 communities that vary on environmental risk regulators. Using a comprehensive electronic health record from a large primary care health system, we will use multilevel and system dynamic models to study the dynamics of obesity in over 55,000 children. We will also conduct a nested substudy of 1150 children from a subset of 80 communities to examine how features of the environment, as well as diet and physical activity alter gene expression as captured by locus-specific DNA methylation in what will be the largest study of its kind to date. We will also employ systems-dynamic models, motivated by real data, to simulate the epidemiologic consequences of policy interventions to up- or down regulate system components identified as determinants of obesity from earlier models.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HD070725-03
Application #
8481564
Study Section
Special Emphasis Panel (ZHD1-DSR-A)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
3
Fiscal Year
2014
Total Cost
$374,980
Indirect Cost
$92,020
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Lee, Bruce Y; Bartsch, Sarah M; Mui, Yeeli et al. (2017) A systems approach to obesity. Nutr Rev 75:94-106
Kim, Mhinjine; Budd, Nadine; Batorsky, Benjamin et al. (2017) Barriers to and Facilitators of Stocking Healthy Food Options: Viewpoints of Baltimore City Small Storeowners. Ecol Food Nutr 56:17-30
Powell-Wiley, Tiffany M; Wong, Michelle S; Adu-Brimpong, Joel et al. (2017) Simulating the Impact of Crime on African American Women's Physical Activity and Obesity. Obesity (Silver Spring) 25:2149-2155
Lee, Bruce Y; Ferguson, Marie C; Hertenstein, Daniel L et al. (2017) Simulating the Impact of Sugar-Sweetened Beverage Warning Labels in Three Cities. Am J Prev Med :
Lee, Bruce Y; Mueller, Leslie E; Tilchin, Carla G (2017) A systems approach to vaccine decision making. Vaccine 35 Suppl 1:A36-A42
Beheshti, Rahmatollah; Jalalpour, Mehdi; Glass, Thomas A (2017) Comparing methods of targeting obesity interventions in populations: An agent-based simulation. SSM Popul Health 3:211-218
Mui, Yeeli; Jones-Smith, Jessica C; Thornton, Rachel L J et al. (2017) Relationships between Vacant Homes and Food Swamps: A Longitudinal Study of an Urban Food Environment. Int J Environ Res Public Health 14:
Zhang, Xin-Yu; Gao, Ying; Li, Chang-Ping et al. (2017) Observed and projected trends in paediatric health resources and services in China between 2003 and 2030: a time-series study. BMJ Open 7:e015000
Bartsch, S M; McKinnell, J A; Mueller, L E et al. (2017) Potential economic burden of carbapenem-resistant Enterobacteriaceae (CRE) in the United States. Clin Microbiol Infect 23:48.e9-48.e16
Hopkins, Laura C; Sattler, Melissa; Steeves, Elizabeth Anderson et al. (2017) Breakfast Consumption Frequency and Its Relationships to Overall Diet Quality, Using Healthy Eating Index 2010, and Body Mass Index among Adolescents in a Low-Income Urban Setting. Ecol Food Nutr 56:297-311

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