This study will extend existing data and ongoing research to understand the dynamics of childhood obesity in a large population of children living in 400 communities that vary on environmental risk regulators. Using a comprehensive electronic health record from a large primary care health system, we will use multilevel and system dynamic models to study the dynamics of obesity in over 55,000 children. We will also conduct a nested substudy of 1150 children from a subset of 80 communities to examine how features of the environment, as well as diet and physical activity alter gene expression as captured by locus-specific DNA methylation in what will be the largest study of its kind to date. We will also employ systems-dynamic models, motivated by real data, to simulate the epidemiologic consequences of policy interventions to up- or down regulate system components identified as determinants of obesity from earlier models.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HD070725-03
Application #
8481564
Study Section
Special Emphasis Panel (ZHD1-DSR-A)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
3
Fiscal Year
2014
Total Cost
$374,980
Indirect Cost
$92,020
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Lee, Bruce Y; Bartsch, Sarah M; Wong, Kim F et al. (2016) The Potential Trajectory of Carbapenem-Resistant Enterobacteriaceae, an Emerging Threat to Health-Care Facilities, and the Impact of the Centers for Disease Control and Prevention Toolkit. Am J Epidemiol 183:471-9
Xue, Hong; Wu, Yang; Wang, Xiaoyu et al. (2016) Time Trends in Fast Food Consumption and Its Association with Obesity among Children in China. PLoS One 11:e0151141
Barnes, Timothy L; Pelletier, Jennifer E; Erickson, Darin J et al. (2016) Healthfulness of Foods Advertised in Small and Nontraditional Urban Stores in Minneapolis-St. Paul, Minnesota, 2014. Prev Chronic Dis 13:E153
Carnell, S; Pryor, K; Mais, L A et al. (2016) Lunch-time food choices in preschoolers: Relationships between absolute and relative intakes of different food categories, and appetitive characteristics and weight. Physiol Behav 162:151-60
Schwartz, Brian S; Glass, Thomas A; Pollak, Jonathan et al. (2016) Depression, its comorbidities and treatment, and childhood body mass index trajectories. Obesity (Silver Spring) 24:2585-2592
Chodur, Gwen M; Shen, Ye; Kodish, Stephen et al. (2016) Food Environments around American Indian Reservations: A Mixed Methods Study. PLoS One 11:e0161132
Chen, Hsin-Jen; Wang, Youfa (2016) Changes in the Neighborhood Food Store Environment and Children's Body Mass Index at Peripuberty in the United States. J Adolesc Health 58:111-8
Lee, Bruce Y; Bartsch, Sarah M; Wong, Kim F et al. (2016) Beyond the Intensive Care Unit (ICU): Countywide Impact of Universal ICU Staphylococcus aureus Decolonization. Am J Epidemiol 183:480-9
Zhang, Ji; Xue, Hong; Cheng, Xi et al. (2016) Influence of proximities to food establishments on body mass index among children in China. Asia Pac J Clin Nutr 25:134-41
Sato, Priscila M; Steeves, Elizabeth A; Carnell, Susan et al. (2016) A youth mentor-led nutritional intervention in urban recreation centers: a promising strategy for childhood obesity prevention in low-income neighborhoods. Health Educ Res 31:195-206

Showing the most recent 10 out of 94 publications