The proposed UNC IDDRC 'Clinical Translational Core'(CTC) includes services to maximize participation of research subjects in IDDRC research (the Participant Registries, or 'PR'), and services to support multi-modal brain imaging, EEG/ERP and eye tracking studies, including development of novel image processing tools (the Brain Measurement Laboratories, or BML) (see Figure 1). BML services provide clinically-relevant insights into (1) early risk markers;(2) brain targets for therapeutics;(3) neural metrics characterizing the impact of intervention;and (4) brain mechanisms, leading to targeted approaches to intervention. The CTC services complement those of the Preclinical Core, promoting links between human and animal model brain and behavior phenotypes. The overarching structure of these hwo cores promotes integration of clinical and preclinical research relevant to understanding the pathogenesis and treatment of intellectual and developmental disabilities, (IDDs).
Specific Aims of the CTC are:
AIM 1. To maximize recruitment of research subjects for clinical studies. Specifically, the PR maintains four participant registries: The Autism Registry (N=5,677);The Fragile X (FX) Registry (N=848);The Child Development Registry (N=8107 typically developing children aged 3 months to 17 years);and the recently established General IDD Registry (N=82), based primarily on patients seen in local clinics. The function of the PR is to: support subject recruitment;maintain accurate, up-to-date consent, contact and clinical information;facilitate subject contact;track participation to limit subject burden;provide feedback to families to increase participation; assist investigators with grant preparation;and facilitate sharing of subject descriptive data among investigators; and collaboration with other local and national registries.
AIM 2. To provide cutting-edge tools, services, resources, expert consultation and training in multimodal brain measurement;Including MRI/DTI/fMRI brain imaging, EEG/ERP and eye-tracking.
AIM 3. To facilitate interdisciplinary and translational IDD research by supporting links between human and animal phenotype studies in the CTC and Preclinical Cores. Specifically, through the liaison roles of Drs. Dawson, Styner, and Paniagua, we will regularly explore areas of overlap in clinical and preclinical studies to foster integration across these domains.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DSR-H (50))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Carolina Chapel Hill
Chapel Hill
United States
Zip Code
Bompard, Lucile; Xu, Shun; Styner, Martin et al. (2014) Multivariate longitudinal shape analysis of human lateral ventricles during the first twenty-four months of life. PLoS One 9:e108306
Lee, Joohwi; Lyu, Ilwoo; Styner, Martin (2014) Multi-atlas segmentation with particle-based group-wise image registration. Proc SPIE Int Soc Opt Eng 9034:903447
Jennings, Joshua H; Stuber, Garret D (2014) Tools for resolving functional activity and connectivity within intact neural circuits. Curr Biol 24:R41-50
Fan, Zheng; Wang, Jiahui; Ahn, Mihye et al. (2014) Characteristics of magnetic resonance imaging biomarkers in a natural history study of golden retriever muscular dystrophy. Neuromuscul Disord 24:178-91
Damiano, Cara R; Mazefsky, Carla A; White, Susan W et al. (2014) Future directions for research in autism spectrum disorders. J Clin Child Adolesc Psychol 43:828-43
Dankoski, Elyse C; Agster, Kara L; Fox, Megan E et al. (2014) Facilitation of serotonin signaling by SSRIs is attenuated by social isolation. Neuropsychopharmacology 39:2928-37