The present application seeks funding to establish an Intellectual and Developmental Disabilities Research Center (IDDRC) at the University of California, which will be fully integrated into, and benefit from, the existing resources of the UC Davis MIND Institute and its campus partners. The MIND Institute is an integrated program that is internationally recognized for ground-breaking studies of autism, fragile X syndrome, and other IDD conditions. The proposed IDDRC includes three components. First, we propose a research component that addresses the focus area of Multi-Modal Treatment Approaches. This component includes a clinical trial targeting children with fragile X syndrome that combines a drug (lovastatin) with a parent-implemented intervention. Novel outcome measures focusing on language and challenging behavior will evaluate efficacy. The clinical trial will be accompanied by studies focused on FMRI-related signaling pathways so as to illuminate the mechanisms by which treatment achieves its effects and to identify biomarkers that indicate treatment efficacy and individual differences in response to treatment. Second, we propose for inclusion 56 IDD-related projects funded by NIH and other federal and private sources. Ten of the projects are funded by NICHD. These projects address three scientific themes: Integrated Biobehavioral Characterization of IDD, Environmental Contributions to IDD, and Treatments for IDD. Third, we propose core components to facilitate interdisciplinary, translational research in IDD. The cores include an Administrative Core and a Clinical Translational Core, with the latter focused on recruitment and diagnostic characterization of human participants. The remaining cores will provide assays of immune function, cellular and molecular biology and imaging, and environmental contaminants (Biological Analysis Core);measures of complex human behavior, particularly for establishing endophenotypes (Neurobehavioral Analysis Core);assays of rodent behavior for evaluating mutant rodent models and supporting preclinical evaluations of drug safety and efficacy (Rodent Behavior Core);and the management and analysis of complex multidimensional data derived from human and animal studies (Biostatistics, Bioinformatics, and Research Design).

Public Health Relevance

The proposed IDDRC is designed to support a translational science agenda focused on IDD. The IDDRC will integrate research from multiple disciplines and bridge basic and clinical science to arrive at treatments for IDD conditions. The range of IDD conditions include autism spectrum disorder, fragile X syndrome, Down syndrome, ADHD, chromosome 22q11.2 deletion syndrome, and many others.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HD079125-02
Application #
8740539
Study Section
Special Emphasis Panel (ZHD1-DSR-H (50))
Program Officer
Parisi, Melissa
Project Start
2013-09-24
Project End
2018-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
2
Fiscal Year
2014
Total Cost
$1,246,354
Indirect Cost
$437,033
Name
University of California Davis
Department
Psychiatry
Type
Schools of Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Roberts, Jane E; Ezell, Jordan E; Fairchild, Amanda J et al. (2018) Biobehavioral composite of social aspects of anxiety in young adults with fragile X syndrome contrasted to autism spectrum disorder. Am J Med Genet B Neuropsychiatr Genet 177:665-675
Sowell, K D; Uriu-Adams, J Y; Van de Water, J et al. (2018) Implications of altered maternal cytokine concentrations on infant outcomes in children with prenatal alcohol exposure. Alcohol 68:49-58
Ly, Calvin; Greb, Alexandra C; Cameron, Lindsay P et al. (2018) Psychedelics Promote Structural and Functional Neural Plasticity. Cell Rep 23:3170-3182
Stahmer, Aubyn C; Suhrheinrich, Jessica; Schetter, Patricia L et al. (2018) Exploring multi-level system factors facilitating educator training and implementation of evidence-based practices (EBP): a study protocol. Implement Sci 13:3
McDuffie, Andrea; Banasik, Amy; Bullard, Lauren et al. (2018) Distance delivery of a spoken language intervention for school-aged and adolescent boys with fragile X syndrome. Dev Neurorehabil 21:48-63
Stamou, Marianna; Grodzki, Ana Cristina; van Oostrum, Marc et al. (2018) Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex. J Neuroinflammation 15:7
Avino, Thomas A; Barger, Nicole; Vargas, Martha V et al. (2018) Neuron numbers increase in the human amygdala from birth to adulthood, but not in autism. Proc Natl Acad Sci U S A 115:3710-3715
Miller, Meghan; Iosif, Ana-Maria; Young, Gregory S et al. (2018) Early Detection of ADHD: Insights From Infant Siblings of Children With Autism. J Clin Child Adolesc Psychol 47:737-744
Ozonoff, Sally; Gangi, Devon; Hanzel, Elise P et al. (2018) Onset patterns in autism: Variation across informants, methods, and timing. Autism Res 11:788-797
Del Hoyo Soriano, Laura; Thurman, Angela John; Abbeduto, Leonard (2018) Specificity: A Phenotypic Comparison of Communication-Relevant Domains Between Youth With Down Syndrome and Fragile X Syndrome. Front Genet 9:424

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