This U54 application seeks renewed funding for Vanderbilt University's Intellectual and Developmental Disabilities Research Center (IDDRC), based in Vanderbilt's Kennedy Center. Vanderbilt's IDDRC includes the full range of basic, clinical, and intervention scientists necessary to fulfill the goals for the EKS NICHD IDDRC program of translational research that improves the lives of people with intellectual and developmental disabilities (IDD) and their families. Our IDDRC focuses on elucidating mechanisms and effective interventions for individuals with autism spectrum disorders, learning disabilities, genetic IDD syndromes, and acquired IDDs. Within each of these groups, IDDRC investigators discover underlying disease mechanisms, treatment targets, and aberrant developmental processes in model systems; assess cognitive, social, emotional, and neural phenotypes; and conduct innovative treatment and intervention studies. These activities are embodied in the U54 Research Project, Sensory and Multisensory Contributions to Autism, which meets the EKS NICHD Focus Theme #2: Outcome Measures for Interventions, and highlights an understudied but increasingly recognized characteristic of autism. Vanderbilt's U54 IDDRC includes 46 investigators from 15 academic departments who lead 69 research projects; 14 are funded by the EKS NICHD. We propose five exceptional, non-duplicative IDDRC Cores to support these investigators and that are also integrated into each Specific Aim of the U54 Research Project. The Administrative Core A provides scientific direction, manages IDDRC governance committees and activities, and leads innovative training and educational programs. Clinical Translational Core B meets investigators' immediate needs for recruiting and phenotyping participants with IDDs, while also assisting with clinical trials, mining novel epidemiological data for IDD phenotyping, and building a new resource of IDD outcome measures. Translational Neuroimaging Core C assists investigators with neuroimaging and psychophysiology data acquisition, processing, and analyses; creates novel experimental paradigms, and proposes big data approaches for large-scale investigations of IDD. Neuroscience Core D provides essential and inherently generative services in mouse neurobehavioral phenotyping, neurochemistry, molecular neurobiology and genomics, and scientific instrumentation, which designs, constructs, or repairs specialized research equipment. Biostatistics and Bioinformatics Core E improves research quality with expert biostatistical consultation and training on topics that are relevant to IDDs, and also develops unique bioinformatics databases of electronic medical record data from patients with IDDs that are linked to their DNA. IDDRC Cores are thus customized to meet the immediate needs of our investigators, and also to generate novel, forward-thinking technologies, tools, or resources that drive innovative discoveries aimed at understanding and ameliorating IDDs.

Public Health Relevance

The Vanderbilt Kennedy Center's IDDRC provides 5 critical Core research services to be used by 46 accomplished investigators, including a U54 Research Project on Sensory and Multisensory Contributions to Autism (EKS NICHD Focus Theme #2). Shared Cores reduce study costs and enable researchers to use cutting-edge approaches that advance basic or clinical discoveries that lead to more effective interventions or treatments for individuals with autism, learning disabilities, genetic IDD syndromes, and acquired IDDs.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZHD1-DSR-H (40))
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Parisi, Melissa, MD, Phd
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Vanderbilt University Medical Center
Other Health Professions
Schools of Medicine
United States
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Butera, Iliza M; Stevenson, Ryan A; Mangus, Brannon D et al. (2018) Audiovisual Temporal Processing in Postlingually Deafened Adults with Cochlear Implants. Sci Rep 8:11345
Patael, Smadar Z; Farris, Emily A; Black, Jessica M et al. (2018) Brain basis of cognitive resilience: Prefrontal cortex predicts better reading comprehension in relation to decoding. PLoS One 13:e0198791
Key, Alexandra P; Jones, Dorita; Peters, Sarika et al. (2018) Feasibility of using auditory event-related potentials to investigate learning and memory in nonverbal individuals with Angelman syndrome. Brain Cogn 128:73-79
Huang, Yali; Bailey, Stephen K; Wang, Peiguang et al. (2018) Voxel-wise detection of functional networks in white matter. Neuroimage 183:544-552
Simon, David M; Nidiffer, Aaron R; Wallace, Mark T (2018) Single Trial Plasticity in Evidence Accumulation Underlies Rapid Recalibration to Asynchronous Audiovisual Speech. Sci Rep 8:12499
Feldman, Jacob I; Kuang, Wayne; Conrad, Julie G et al. (2018) Brief Report: Differences in Multisensory Integration Covary with Sensory Responsiveness in Children with and without Autism Spectrum Disorder. J Autism Dev Disord :
Giraldo-Chica, Monica; Rogers, Baxter P; Damon, Stephen M et al. (2018) Prefrontal-Thalamic Anatomical Connectivity and Executive Cognitive Function in Schizophrenia. Biol Psychiatry 83:509-517
Zengin-Bolatkale, Hatun; Conture, Edward G; Walden, Tedra A et al. (2018) Sympathetic arousal as a marker of chronicity in childhood stuttering. Dev Neuropsychol 43:135-151
Matusz, Pawel J; Key, Alexandra P; Gogliotti, Shirley et al. (2018) Somatosensory Plasticity in Pediatric Cerebral Palsy following Constraint-Induced Movement Therapy. Neural Plast 2018:1891978
Damiano-Goodwin, Cara R; Woynaroski, Tiffany G; Simon, David M et al. (2018) Developmental sequelae and neurophysiologic substrates of sensory seeking in infant siblings of children with autism spectrum disorder. Dev Cogn Neurosci 29:41-53

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