Description: The Administrative Core provides oversight for overall Center function, including the research, educational and advocacy missions. The core executes these roles through the following activities: (1) ADMINISTRATIVE OVERSIGHT: (a) Overall governance of the IDDRC; (b) Communications with NICHD, including submission of annual progress reports; (c) Circulation of all relevant announcements; (d) Management of the IDDRC budget; (e) Organization and convening of the Internal and External Advisory Committees; (2) RESEARCH MISSION: (a) Oversee admission of new projects to the Center; (b) Ongoing assessment of core services, including regular reviews of user satisfaction; (c) Bring in new research services when requested by users; (3) EDUCATIONAL PROGRAM: (a) Organize Monthly IDDRC Seminar and the Monthly ?Chalk Talk? Series; (b) Administer IDDRC-sponsored awards, including the Alavi-Dabiri Award, New Program Development Supplement for Clinician Trainee Stipends, and the McMorris Fellowship; (c) Support T32 Training Grant in Neurodevelopmental Disabilities; (4) ADVOCACY MISSION: (a) Participate in IDDRC Network to advance agenda of IDD Branch of NICHD; (b) Promote recruitments of high-quality investigators in field of IDD-related research; (c) Foster inter-disciplinary IDD-related research by working with Administration to create Centers of Excellence; (d) Collaborate with community support/patient groups, to: (i) Advocate for their needs, (ii) Sponsor educational seminars for a lay audience, and (iii) Create and support opportunities for families to gather and exchange information; (iv) Advise support groups regarding latest scientific advances; (e) Work with departments of health (NJ, PA, DE) to improve newborn screening services for inherited disease. Relevance to IDDRC Mission: Our Center enhances IDD-related research in 4 ways: (a) Creating a sense of ?IDD Community?, thereby favoring allocation of resources for IDD research; (b) Support for core laboratories (c) Recruiting young people into the field; (d) Working with the Network to foster collaboration and promote the goals of the IDD Branch of NICHD. The Administrative Core is essential to each function. It ensures that: (a) Core laboratories provide state-of-the-art services; (b) IDD research figures prominently in the institutional agenda, and that the CHOP/UPenn research community is supported in their rapidly adapting to and incorporating innovations that emerge, which will advance IDD research; (c) Young investigators are drawn to the field; and (d) The Network is an effective instrument for advocacy.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZHD1)
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Children's Hospital of Philadelphia
United States
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Thapar, A; Martin, J; Mick, E et al. (2016) Psychiatric gene discoveries shape evidence on ADHD's biology. Mol Psychiatry 21:1202-7
Ali, Zarina S; Johnson, Victoria E; Stewart, William et al. (2016) Neuropathological Characteristics of Brachial Plexus Avulsion Injury With and Without Concomitant Spinal Cord Injury. J Neuropathol Exp Neurol 75:69-85
Sengupta, Shaon; Yang, Guang; O'Donnell, John C et al. (2016) The circadian gene Rev-erbα improves cellular bioenergetics and provides preconditioning for protection against oxidative stress. Free Radic Biol Med 93:177-89
Portnoy, Emma; Polyak, Boris; Inbar, Dorrit et al. (2016) Tracking inflammation in the epileptic rat brain by bi-functional fluorescent and magnetic nanoparticles. Nanomedicine 12:1335-45
Busch, David R; Lynch, Jennifer M; Winters, Madeline E et al. (2016) Cerebral Blood Flow Response to Hypercapnia in Children with Obstructive Sleep Apnea Syndrome. Sleep 39:209-16
Mlynarski, Elisabeth E; Xie, Michael; Taylor, Deanne et al. (2016) Rare copy number variants and congenital heart defects in the 22q11.2 deletion syndrome. Hum Genet 135:273-85
Finkel, Terri H; Li, Jin; Wei, Zhi et al. (2016) Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility. BMC Med Genet 17:24
Herrington, John D; Miller, Judith S; Pandey, Juhi et al. (2016) Anxiety and social deficits have distinct relationships with amygdala function in autism spectrum disorder. Soc Cogn Affect Neurosci 11:907-14
Falk, Marni J; Shen, Lishuang; Gai, Xiaowu (2016) From case studies to community knowledge base: MSeqDR provides a platform for the curation and genomic analysis of mitochondrial diseases. Cold Spring Harb Mol Case Stud 2:a001065
Berman, J I; Chudnovskaya, D; Blaskey, L et al. (2016) Relationship between M100 Auditory Evoked Response and Auditory Radiation Microstructure in 16p11.2 Deletion and Duplication Carriers. AJNR Am J Neuroradiol 37:1178-84

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