Abstract

CLINICAL TRANSLATIONAL CORE (CORE B) ABSTRACT The objectives of the new Clinical Translational Core of our IDDRC are to accelerate the translation of research discoveries into new treatments for neurodevelopmental disorders, through collaboration with basic scientists and clinicians, as well as to train future leaders in translational neuroscience. Resources offered by the Clinical Translational Core include preclinical support through a Human Neuron Core Component, composed of a Cellular Assay Development and Screening Service and a Human Neuron Differentiation Service. Additionally, support for translational work includes resources through a Clinical and Regulatory Affairs Service, a Data Analysis Core Component, Biorepository and preclinical consultation. The core has a proven record of success in designing and launching preclinical and clinical projects for IDDRC investigators.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54HD090255-01
Application #
9229203
Study Section
Special Emphasis Panel (ZHD1-DSR-H (50))
Project Start
2016-09-23
Project End
2021-05-31
Budget Start
2016-09-01
Budget End
2017-05-31
Support Year
1
Fiscal Year
2016
Total Cost
$143,952
Indirect Cost
$62,623

  Institution

Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Modi, Meera E; Sahin, Mustafa (2018) A unified circuit for social behavior. Neurobiol Learn Mem :
Beggs, Alan H; Byrne, Barry J; De Chastonay, Sabine et al. (2018) A multicenter, retrospective medical record review of X-linked myotubular myopathy: The recensus study. Muscle Nerve 57:550-560
Asai, Yukako; Pan, Bifeng; Nist-Lund, Carl et al. (2018) Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1. Sci Rep 8:12124
Mavros, Chrystal F; Brownstein, Catherine A; Thyagrajan, Roshni et al. (2018) De novo variant of TRRAP in a patient with very early onset psychosis in the context of non-verbal learning disability and obsessive-compulsive disorder: a case report. BMC Med Genet 19:197
Hrvatin, Sinisa; Hochbaum, Daniel R; Nagy, M Aurel et al. (2018) Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex. Nat Neurosci 21:120-129
Wallace, David K; Dean, Trevano W; Hartnett, Mary Elizabeth et al. (2018) A Dosing Study of Bevacizumab for Retinopathy of Prematurity: Late Recurrences and Additional Treatments. Ophthalmology 125:1961-1966
Schwartz, Talia S; Wojcik, Monica H; Pelletier, Renee C et al. (2018) Expanding the phenotypic spectrum associated with OPHN1 variants. Eur J Med Genet :
Marsh, Ashley P L; Edwards, Timothy J; Galea, Charles et al. (2018) DCC mutation update: Congenital mirror movements, isolated agenesis of the corpus callosum, and developmental split brain syndrome. Hum Mutat 39:23-39
Sveinsdóttir, Kristbjörg; Ley, David; Hövel, Holger et al. (2018) Relation of Retinopathy of Prematurity to Brain Volumes at Term Equivalent Age and Developmental Outcome at 2 Years of Corrected Age in Very Preterm Infants. Neonatology 114:46-52
Sieberg, Christine B; Taras, Caitlin; Gomaa, Aya et al. (2018) Neuropathic pain drives anxiety behavior in mice, results consistent with anxiety levels in diabetic neuropathy patients. Pain Rep 3:e651

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