Abstract

? ? The St. Jude Comprehensive Sickle Cell Center proudly presents its competitive renewal grant application in response to RFA-HL-06-008 entitled, """"""""Comprehensive Sickle Cell Centers"""""""". Over the past 5 years, St. Jude Children's Research Hospital (SJCRH) has established a premier Comprehensive Sickle Cell Center that conducts cutting-edge basic and clinical research, provides state-of-the art clinical care and patient services, and offers outstanding education and training related to sickle cell disease (SCD). As a member of the NHLBI CSCC network comprised often Comprehensive Sickle Cell Centers, St. Jude has distinguished itself with outstanding enrollment, participation, and leadership for approved inter-Center network projects. For the upcoming 5-year funding cycle, St. Jude will continue this strong track record of excellence, but will expand efforts to include SCD translational and patient services outcomes research, and also will offer a robust commitment to medical care and research for adults with SCD through newly established collaborations with the University of Tennessee (UT) at both the Diggs-Kraus Sickle Cell Center and the UT Cancer Institute. The St. Jude Comprehensive Sickle Cell Center remains committed to advancing understanding of disease pathophysiology, to improving medical management modalities, and to developing cures for SCD. ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
2U54HL070590-06
Application #
7343448
Study Section
Special Emphasis Panel (ZHL1-CSR-O (F1))
Program Officer
Luksenburg, Harvey
Project Start
2003-07-01
Project End
2012-03-31
Budget Start
2008-06-18
Budget End
2009-03-31
Support Year
6
Fiscal Year
2008
Total Cost
$1,263,523
Indirect Cost

  Institution

Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105

  Publications

Helton, Kathleen J; Glass, John O; Reddick, Wilburn E et al. (2015) Comparing segmented ASL perfusion of vascular territories using manual versus semiautomated techniques in children with sickle cell anemia. J Magn Reson Imaging 41:439-46
Carter, Robert; Wolf, Joshua; van Opijnen, Tim et al. (2014) Genomic analyses of pneumococci from children with sickle cell disease expose host-specific bacterial adaptations and deficits in current interventions. Cell Host Microbe 15:587-599
Winchell, A M; Taylor, B A; Song, R et al. (2014) Evaluation of SWI in children with sickle cell disease. AJNR Am J Neuroradiol 35:1016-21
Nasimuzzaman, Md; Kim, Yoon-Sang; Wang, Yong-Dong et al. (2014) High-titer foamy virus vector transduction and integration sites of human CD34(+) cell-derived SCID-repopulating cells. Mol Ther Methods Clin Dev 1:14020
Henriques-Normark, Birgitta; Tuomanen, Elaine I (2013) The pneumococcus: epidemiology, microbiology, and pathogenesis. Cold Spring Harb Perspect Med 3:
Nasimuzzaman, Md; Persons, Derek A (2012) Cell Membrane-associated heparan sulfate is a receptor for prototype foamy virus in human, monkey, and rodent cells. Mol Ther 20:1158-66
Lebensburger, Jeffrey D; Howard, Thad; Hu, Yunming et al. (2012) Hydroxyurea therapy of a murine model of sickle cell anemia inhibits the progression of pneumococcal disease by down-modulating E-selectin. Blood 119:1915-21
Mann, Beth; van Opijnen, Tim; Wang, Jianmin et al. (2012) Control of virulence by small RNAs in Streptococcus pneumoniae. PLoS Pathog 8:e1002788
McGann, Patrick T; Flanagan, Jonathan M; Howard, Thad A et al. (2012) Genotoxicity associated with hydroxyurea exposure in infants with sickle cell anemia: results from the BABY-HUG Phase III Clinical Trial. Pediatr Blood Cancer 59:254-7
Song, Ruitian; Loeffler, Ralf B; Hillenbrand, Claudia M (2012) QUIPSS II with window-sliding saturation sequence (Q2WISE). Magn Reson Med 67:1127-32

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