The Project Leaders of the Emory/Children's TRC-THD Center application are basic, translational and clinical research scientists who have a strong interest in hemostasis and thrombosis. The Aflac Cancer Center and Blood Disorders Service Hemostasis and Thrombosis Program (Aflac HT Program) includes three young faculty investigators, Shannon Meeks, M.D., Wilbur Lam, M.D., Ph.D., and Amy Dunn, M.D., who will advance to more senior status by enhancing their research skills as Project Leaders. Additionally, the Aflac HT Program includes a young clinician scientist. Ana Antun, M.D., who recently completed her fellowship training in hematology and will enter the ACTSI MSCR program. Additionally, the Aflac HT Program has an extensive history of training medical students, Ph.D. and M.D./Ph.D. graduate students and clinical fellows and will continue to expand in this area as it continues to grow.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54HL112309-01
Application #
8392591
Study Section
Special Emphasis Panel (ZHL1-CSR-C (F1))
Project Start
2012-05-01
Project End
2017-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
1
Fiscal Year
2012
Total Cost
$315,411
Indirect Cost
$110,383
Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Healey, J F; Parker, E T; Lollar, P (2017) Identification of Aggregates in Therapeutic Formulations of Recombinant Full-Length Factor VIII Products by Sedimentation Velocity Analytical Ultracentrifugation. J Thromb Haemost :
Carden, Marcus A; Fay, Meredith E; Lu, Xinran et al. (2017) Extracellular fluid tonicity impacts sickle red blood cell deformability and adhesion. Blood 130:2654-2663
Deng, W; Wang, Y; Druzak, S A et al. (2017) A discontinuous autoinhibitory module masks the A1 domain of von Willebrand factor. J Thromb Haemost 15:1867-1877
Mannino, Robert G; Santiago-Miranda, Adriana N; Pradhan, Pallab et al. (2017) 3D microvascular model recapitulates the diffuse large B-cell lymphoma tumor microenvironment in vitro. Lab Chip 17:407-414
Myers, David R; Qiu, Yongzhi; Fay, Meredith E et al. (2017) Single-platelet nanomechanics measured by high-throughput cytometry. Nat Mater 16:230-235
Qiu, Yongzhi; Tong, Sheng; Zhang, Linlin et al. (2017) Magnetic forces enable controlled drug delivery by disrupting endothelial cell-cell junctions. Nat Commun 8:15594
Zerra, Patricia E; Cox, Courtney; Baldwin, W Hunter et al. (2017) Marginal zone B cells are critical to factor VIII inhibitor formation in mice with hemophilia A. Blood 130:2559-2568
Kahle, Joerg; Orlowski, Aleksander; Stichel, Diana et al. (2017) Frequency and epitope specificity of anti-factor VIII C1 domain antibodies in acquired and congenital hemophilia A. Blood 130:808-816
Zakas, Philip M; Brown, Harrison C; Knight, Kristopher et al. (2017) Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction. Nat Biotechnol 35:35-37
Batsuli, Glaivy; Deng, Wei; Healey, John F et al. (2016) High-affinity, noninhibitory pathogenic C1 domain antibodies are present in patients with hemophilia A and inhibitors. Blood 128:2055-2067

Showing the most recent 10 out of 31 publications