ADMINSTRATIVE COORDINATING CENTER (ACC) Emory-Children's will serve as the Administrative Coordinating Center (ACC) for the TRC-THD Centers. The ACC will facilitate interactions between the TRC-THD Centers that are designed to identify ways in which the centers can collaborate, share information (and possibly specimens), and maximize resources. These Interactions will be accomplished by organizing Investigator and External Panel meetings, coordinating conference calls, and designing and maintaining a website for the TRC-THD program. This website will be developed in conjunction with the Research Health Sciences Information Technology Division and its affiliation with the Atlanta Clinical and Translational Science Institute. With oversight by the NHLBI, the Administrative Coordinating Center will bring together a large and multidisciplinary community of TRC-THD Centers that will support excellence in research in hemostasis and thrombosis by anticipating and allowing fluidity to accommodate changes and progress in the fleld. By providing a central administrative structure, the ACC will foster a unique collaborative research community during the course of the funding years and in the years beyond.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HL112309-02
Application #
8464237
Study Section
Special Emphasis Panel (ZHL1-CSR-C)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
2
Fiscal Year
2013
Total Cost
$132,831
Indirect Cost
$47,028
Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Zakas, P M; Vanijcharoenkarn, K; Markovitz, R C et al. (2015) Expanding the ortholog approach for hemophilia treatment complicated by factor VIII inhibitors. J Thromb Haemost 13:72-81
Lollar, Pete; Winzor, Donald J (2014) Reconciliation of classical and reacted-site probability approaches to allowance for ligand multivalence in binding studies. J Mol Recognit 27:73-81
Qiu, Yongzhi; Brown, Ashley C; Myers, David R et al. (2014) Platelet mechanosensing of substrate stiffness during clot formation mediates adhesion, spreading, and activation. Proc Natl Acad Sci U S A 111:14430-5
Nguyen, Phuong-Cac T; Lewis, Kenneth B; Ettinger, Ruth A et al. (2014) High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance. Blood 123:2732-9
Ciciliano, Jordan C; Tran, Reginald; Sakurai, Yumiko et al. (2014) The platelet and the biophysical microenvironment: lessons from cellular mechanics. Thromb Res 133:532-7
Markovitz, Rebecca C; Healey, John F; Parker, Ernest T et al. (2013) The diversity of the immune response to the A2 domain of human factor VIII. Blood 121:2785-95
Walter, Justin D; Werther, Rachel A; Polozova, Maria S et al. (2013) Characterization and solution structure of the factor VIII C2 domain in a ternary complex with classical and non-classical inhibitor antibodies. J Biol Chem 288:9905-14