There is an urgent need for reducing or eliminating many health disparities that affect underserved minority populations. Despite important advances in knowledge about the basic mechanisms of disease, translation of this knowledge to treatment and prevention of disease has been limited and slow, in particular for these underserved ethnic and racial minorities. The Puerto Rico Clinical and Translational Research Consortium (PRCTRC) will be established as the concept that will advance this translation of knowledge and have an impact on these disparities. It will be a centralized clinical and translational research program focused on health problems prevalent in an underserved minority population and establishing a multidisciplinary and collaborative effort between three major academic health care institutions in Puerto Rico. The major programmatic goals are to: 1) To enhance and integrate existing infrastructure for clinical and translational research to support and expand Clinical and Translational Research in the Health Disparities;2) To enhance and support existing training and mentoring programs to increase the number of new minority investigators in Clinical and Translational Research;3)To facilitate the translation of knowledge from the bench into the community. To accomplish these goals we will integrate, expand and enhance: 1) Participant and Clinical Interaction Resources 2) Clinical and Translational Research core resources in Biostatistics and Data Management 3) Core laboratories and technologies 4) Training and developmental programs 5) Support for regulatory compliance resources 6)informatic resources 7) Community interactions and participation programs. The proposed program will be integrative, incorporating resources and leadership from all three institutions, many of these under the RCMI-Clinical Research Center (RCMI-CRC) and the Comprehensive Center for Health Disparities (CCHD) but fusing under a single administrative structure. The proposed program will be inclusive, incorporating leadership from all the participating institutions at several levels of administrative responsibility. It will be novel, because it will provide a unique opportunity to incorporate resources and have an impact across a state-size territory composed primarily of a minority population.

Public Health Relevance

The proposed program will help advance knowledge about conditions that disproportionately affect minority populations and will provide a platform for more efficient collaborations among institutions that serve these populations. By enhancing and consolidating existing resources it will facilitate the discovery of new knowledge in patient-oriented research and will aid in the development of new, clinical and translational minority researchers.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
8U54MD007587-03
Application #
8300172
Study Section
Special Emphasis Panel (ZRR1-RI-1 (02))
Program Officer
Arora, Krishan
Project Start
2010-09-17
Project End
2014-06-30
Budget Start
2012-07-12
Budget End
2014-06-30
Support Year
3
Fiscal Year
2012
Total Cost
$4,090,475
Indirect Cost
$1,116,275
Name
University of Puerto Rico Med Sciences
Department
None
Type
Schools of Medicine
DUNS #
948108063
City
San Juan
State
PR
Country
United States
Zip Code
00936
Rachlis, Beth; Karwa, Rakhi; Chema, Celia et al. (2016) Targeted Spontaneous Reporting: Assessing Opportunities to Conduct Routine Pharmacovigilance for Antiretroviral Treatment on an International Scale. Drug Saf 39:959-76
Orellano-Colón, Elsa M; Mann, William C; Rivero, Marta et al. (2016) Hispanic Older Adult's Perceptions of Personal, Contextual and Technology-Related Barriers for Using Assistive Technology Devices. J Racial Ethn Health Disparities 3:676-686
Buchacz, Kate; Lau, Bryan; Jing, Yuezhou et al. (2016) Incidence of AIDS-Defining Opportunistic Infections in a Multicohort Analysis of HIV-infected Persons in the United States and Canada, 2000-2010. J Infect Dis 214:862-72
Abreu-Delgado, Yamilka; Isidro, Raymond A; Torres, Esther A et al. (2016) Serum vitamin D and colonic vitamin D receptor in inflammatory bowel disease. World J Gastroenterol 22:3581-91
G Clifton, Rebecca; Evans, Mary; Cahill, Alison G et al. (2016) Design of lifestyle intervention trials to prevent excessive gestational weight gain in women with overweight or obesity. Obesity (Silver Spring) 24:305-13
Cumba-Avilés, Eduardo; Sáez-Santiago, Emily (2016) Research Program on Type 1 Diabetes and Youth Depression in Puerto Rico. Rev Puertorriquena Psicol 27:44-60
Ortiz-Martínez, Mario G; Frías-Belén, Orquídea; Nazario-Jiménez, Sylvette et al. (2016) A case-control study of innate immunity pathway gene polymorphisms in Puerto Ricans reveals association of toll-like receptor 2 +596 variant with asthma. BMC Pulm Med 16:112
Marqués-Lespier, Juan M; González-Pons, María; Cruz-Correa, Marcia (2016) Current Perspectives on Gastric Cancer. Gastroenterol Clin North Am 45:413-28
Fred-Jiménez, Ruth M; Arroyo-Ávila, Mariangelí; Mayor, Ángel M et al. (2016) Clinical Manifestations Associated with Overweight/Obesity in Puerto Ricans with Fibromyalgia Syndrome. J Obes 2016:1379289
Koethe, John R; Jenkins, Cathy A; Lau, Bryan et al. (2016) Rising Obesity Prevalence and Weight Gain Among Adults Starting Antiretroviral Therapy in the United States and Canada. AIDS Res Hum Retroviruses 32:50-8

Showing the most recent 10 out of 172 publications