Obesity is recognized as the essential component of the metabolic syndrome, a pro-inflammatory state characterized by biomarkers of dyslipidemia, hypertension, central obesity, and elevated glucose. Scientists tend to identify only the genetic and behavioral antecedents of this pro-inflammatory state. Conversely, social and psychological researchers recognize a similar construct, allostatic load, also characterized by similar biomarkers. Differential environmental exposure to social stressors, i.e., allostatic load may lead to the pro-inflammatory state associated with metabolic syndrome . The challenge is to understand the link between obesity, metabolic and immunological abnormalities, and social stress. Recent research in adults indicates an increase in adiponectin after consumption of a Mediterranean diet high in fruits and vegetables. Consequently, greater access to fresh fruits and vegetables may contribute to increased adiponectin, reduced inflammation and a lower risk of obesity and metabolic disease. Our previous cross-sectional studies acknowledge that metabolic and pro-inflammatory mediators are over-expressed in youth prior to puberty. Prospective studies in developing children are proposed here to delineate the time course of obesity and metabolic dysfunction in relation to pro and anti-inflammatory markers. Correlating the molecular basis of obesity, one of the primary health disparities in the Deep South, with social determinants of health, e.g. maternal stress, neighborhood deterioration, food and physical activity environment and behavioral factors, e.g. diet and physical activity, assumes a complex, multidimensional effort involving a range of disciplines. Thus, in a multi-ethnic cohort of healthy youth we propose to;I. Examine the relationship of pro-and-antinflammatory SNPs with change in obesity and related metabolic biomarkers from pre-to-post-adolescence and further determine the mediating effect of the change in inflammatory markers during this same time period, II. Examine the contribution of social determinants (stress, food and physical activity environment) to the change in obesity, metabolic health and inflammation from pre-to-post adolescence after considering race, gender, maternal pregnancy weight, breastfeeding duration, diet and physical activity.

Public Health Relevance

Obesity and metabolic disease are serious public health concerns in the United States and major issues among developing youth in the Deep South. The identification of biomarkers at an early age, may offer targets for diagnosis, treatment, and prognosis. Early detection is important given the increasing prevalence in children and the deleterious effect of a prolonged presence of metabolic disease on future morbidity.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54MD008176-03
Application #
8718824
Study Section
Special Emphasis Panel (ZMD1)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
DUNS #
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Booth 3rd, John N; Diaz, Keith M; Seals, Samantha R et al. (2016) Masked Hypertension and Cardiovascular Disease Events in a Prospective Cohort of Blacks: The Jackson Heart Study. Hypertension 68:501-10
Tabatabai, Mohammad A; Kengwoung-Keumo, Jean-Jacques; Oates, Gabriela R et al. (2016) Racial and Gender Disparities in Incidence of Lung and Bronchus Cancer in the United States: A Longitudinal Analysis. PLoS One 11:e0162949
Serrano-Gomez, Silvia Juliana; Sanabria-Salas, Maria Carolina; Hernández-Suarez, Gustavo et al. (2016) High prevalence of luminal B breast cancer intrinsic subtype in Colombian women. Carcinogenesis 37:669-76
Kepper, M; Tseng, T-S; Volaufova, J et al. (2016) Pre-school obesity is inversely associated with vegetable intake, grocery stores and outdoor play. Pediatr Obes 11:e6-8
Joseph, Ann Mary; Srivastava, Ratika; Zabaleta, Jovanny et al. (2016) Cross-talk between 4-1BB and TLR1-TLR2 Signaling in CD8+ T Cells Regulates TLR2's Costimulatory Effects. Cancer Immunol Res 4:708-16
Loupe, Jacob M; Miller, Patrick J; Bonner, Benjamin P et al. (2016) Acquisition of an oncogenic fusion protein serves as an initial driving mutation by inducing aneuploidy and overriding proliferative defects. Oncotarget :
Loupe, J M; Miller, P J; Bonner, B P et al. (2016) Comparative transcriptomic analysis reveals the oncogenic fusion protein PAX3-FOXO1 globally alters mRNA and miRNA to enhance myoblast invasion. Oncogenesis 5:e246
Kepper, Maura; Broyles, Stephanie; Scribner, Richard et al. (2016) Parental Perceptions of the Social Environment Are Inversely Related to Constraint of Adolescents' Neighborhood Physical Activity. Int J Environ Res Public Health 13:
Booth 3rd, John N; Redmond, Nicole; Sims, Mario et al. (2016) The association of reduced lung function with blood pressure variability in African Americans: data from the Jackson Heart Study. BMC Cardiovasc Disord 16:6
Coulon, Sara J; Velasco-Gonzalez, Cruz; Scribner, Richard et al. (2016) Racial differences in neighborhood disadvantage, inflammation and metabolic control in black and white pediatric type 1 diabetes patients. Pediatr Diabetes :

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