Obesity is recognized as the essential component of the metabolic syndrome, a pro-inflammatory state characterized by biomarkers of dyslipidemia, hypertension, central obesity, and elevated glucose. Scientists tend to identify only the genetic and behavioral antecedents of this pro-inflammatory state. Conversely, social and psychological researchers recognize a similar construct, allostatic load, also characterized by similar biomarkers. Differential environmental exposure to social stressors, i.e., allostatic load may lead to the pro-inflammatory state associated with metabolic syndrome . The challenge is to understand the link between obesity, metabolic and immunological abnormalities, and social stress. Recent research in adults indicates an increase in adiponectin after consumption of a Mediterranean diet high in fruits and vegetables. Consequently, greater access to fresh fruits and vegetables may contribute to increased adiponectin, reduced inflammation and a lower risk of obesity and metabolic disease. Our previous cross-sectional studies acknowledge that metabolic and pro-inflammatory mediators are over-expressed in youth prior to puberty. Prospective studies in developing children are proposed here to delineate the time course of obesity and metabolic dysfunction in relation to pro and anti-inflammatory markers. Correlating the molecular basis of obesity, one of the primary health disparities in the Deep South, with social determinants of health, e.g. maternal stress, neighborhood deterioration, food and physical activity environment and behavioral factors, e.g. diet and physical activity, assumes a complex, multidimensional effort involving a range of disciplines. Thus, in a multi-ethnic cohort of healthy youth we propose to;I. Examine the relationship of pro-and-antinflammatory SNPs with change in obesity and related metabolic biomarkers from pre-to-post-adolescence and further determine the mediating effect of the change in inflammatory markers during this same time period, II. Examine the contribution of social determinants (stress, food and physical activity environment) to the change in obesity, metabolic health and inflammation from pre-to-post adolescence after considering race, gender, maternal pregnancy weight, breastfeeding duration, diet and physical activity.

Public Health Relevance

Obesity and metabolic disease are serious public health concerns in the United States and major issues among developing youth in the Deep South. The identification of biomarkers at an early age, may offer targets for diagnosis, treatment, and prognosis. Early detection is important given the increasing prevalence in children and the deleterious effect of a prolonged presence of metabolic disease on future morbidity.

National Institute of Health (NIH)
National Institute on Minority Health and Health Disparities (NIMHD)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZMD1)
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University of Alabama Birmingham
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Clay, Olivio J; Perkins, Martinique; Wallace, Gail et al. (2018) Associations of Multimorbid Medical Conditions and Health-Related Quality of Life Among Older African American Men. J Gerontol B Psychol Sci Soc Sci 73:258-266
Cardel, Michelle I; Min, Yuan-I; Sims, Mario et al. (2018) Association of psychosocial stressors with metabolic syndrome severity among African Americans in the Jackson Heart Study. Psychoneuroendocrinology 90:141-147
Leggett, Sophia S; Wesley, Joan M; Myla, Anitha et al. (2018) Availability and Quality of Physical Activity Resources in Neighborhood Parks for Pregnant Women and Women of Childbearing Age. Prev Chronic Dis 15:E78
Danos, Denise; Leonardi, Claudia; Gilliland, Aubrey et al. (2018) Increased Risk of Hepatocellular Carcinoma Associated With Neighborhood Concentrated Disadvantage. Front Oncol 8:375
Danos, Denise M; Ferguson, Tekeda F; Simonsen, Neal R et al. (2018) Neighborhood disadvantage and racial disparities in colorectal cancer incidence: a population-based study in Louisiana. Ann Epidemiol 28:316-321.e2
Serrano-Gómez, Silvia J; Fejerman, Laura; Zabaleta, Jovanny (2018) Breast Cancer in Latinas: A Focus on Intrinsic Subtypes Distribution. Cancer Epidemiol Biomarkers Prev 27:3-10
Mwasongwe, Stanford; Min, Yuan-I; Booth 3rd, John N et al. (2018) Masked hypertension and kidney function decline: the Jackson Heart Study. J Hypertens 36:1524-1532
Mwasongwe, Stanford E; Young, Bessie; Bidulescu, Aurelian et al. (2018) Relation of multi-marker panel to incident chronic kidney disease and rapid kidney function decline in African Americans: the Jackson Heart Study. BMC Nephrol 19:239
Coulon, Sara J; Velasco-Gonzalez, Cruz; Scribner, Richard et al. (2017) Racial differences in neighborhood disadvantage, inflammation and metabolic control in black and white pediatric type 1 diabetes patients. Pediatr Diabetes 18:120-127
Ferdinand, Rashida; Torres, Rosamar; Scott, Jennifer et al. (2017) Incentivizing Fruit and Vegetable Purchasers at Fresh Markets in Lower 9th Ward, New Orleans. Ethn Dis 27:287-294

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