Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54NS058183-08
Application #
8551628
Study Section
Special Emphasis Panel (ZRG1-MDCN-J)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
8
Fiscal Year
2013
Total Cost
$277,584
Indirect Cost
Name
U.S. Army Medical Research Institute Chem Def
Department
Type
DUNS #
168812329
City
Aberdeen Proving Ground
State
MD
Country
United States
Zip Code
21010
Dwyer, Mary; Javor, Sacha; Ryan, Daniel A et al. (2014) Novel human butyrylcholinesterase variants: toward organophosphonate detoxication. Biochemistry 53:4476-87
Rockah-Shmuel, Liat; Tawfik, Dan S; Goldsmith, Moshe (2014) Generating targeted libraries by the combinatorial incorporation of synthetic oligonucleotides during gene shuffling (ISOR). Methods Mol Biol 1179:129-37
Schneider, Jeannine D; Castilho, Alexandra; Neumann, Laura et al. (2014) Expression of human butyrylcholinesterase with an engineered glycosylation profile resembling the plasma-derived orthologue. Biotechnol J 9:501-10
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Ben-David, Moshe; Wieczorek, Grzegorz; Elias, Mikael et al. (2013) Catalytic metal ion rearrangements underline promiscuity and evolvability of a metalloenzyme. J Mol Biol 425:1028-38
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Goldsmith, Moshe; Ashani, Yacov; Simo, Yair et al. (2012) Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification. Chem Biol 19:456-66
Ben-David, Moshe; Elias, Mikael; Filippi, Jean-Jacques et al. (2012) Catalytic versatility and backups in enzyme active sites: the case of serum paraoxonase 1. J Mol Biol 418:181-96
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