Control of stroke risk factors is suboptimal, especially in minority populations. Los Angeles County is the largest county in the country, and its safety net hospitals serve a predominantly indigent, minority population, so it can serve as a setting for testing new care intervenfions to close racial and ethnic disparifies. We are currently testing a care intervention focusing on system delivery redesign, and we have successfully enrolled over 300 subjects in a randomized-controlled trial, of whom 90% of subjects are nonwhite. We are proposing to enhance this intervenfion by emphasizing a community-centered component of a Chronic Care Model-based intervenfion called Secondary stroke prevenfion by Unifing Community and Chronic care model teams Eariy to End Disparities (SUCCEED). It consists of community health workers (CHWs) visiting patients at home and leading self-management classes in the community. CHWs will also use mobile health technology to foster communication between thenhselves and physician extenders serving as care managers. Finally, subjects will be given blood pressure monitors to collect measurements at home. A steering committee, composed of community leaders, researchers, lay persons, and academic collaborators will ensure that the intervention is culturally tailored. We will then evaluate this enhanced chronic care model-based intervenfion by conducfing a randomized-controlled trial of 500 patients who speak English, Spanish, Korean, Mandarin, or Cantonese, and who have suffered a recent stroke or transient ischemic attack. The study is powered to detect an 8 mm Hg difference in the primary outcome of systolic blood pressure. Secondary outcomes consist of controling other stroke risk factors and improving lifestyle habits. We will also collect a set of mediators and moderators to understand robustness of intervention impacts across levels of individual and health system characteristics. We will also conduct a cost analysis of SUCCEED from the perspective of the Los Angeles County Department of Health Services, and develop a sustainability plan for the Los Angeles County Department of Health Services to maintain SUCCEED after the funding period.

Public Health Relevance

To reduce disparities of stroke prevention, we plan to develop and test a care intervention highlighted by 1) community health workers visifing pafients at home and leading self-management classes in the community and 2) implementation of mobile health technology. This care intervention can serve as a prototype for dissemination to other communifies serving a vulnerable populafion.

National Institute of Health (NIH)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZNS1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Los Angeles
Los Angeles
United States
Zip Code
Hamid, Hamada; Blackmon, Karen; Cong, Xiangyu et al. (2014) Mood, anxiety, and incomplete seizure control affect quality of life after epilepsy surgery. Neurology 82:887-94
Fogel, Brent L; Vickrey, Barbara G; Walton-Wetzel, Jenny et al. (2013) Utilization of genetic testing prior to subspecialist referral for cerebellar ataxia. Genet Test Mol Biomarkers 17:588-94
Berg, Anne T; Baca, Christine B; Loddenkemper, Tobias et al. (2013) Priorities in pediatric epilepsy research: improving children's futures today. Neurology 81:1166-75
Brown, Arleen F; Liang, Li-Jung; Vassar, Stefanie D et al. (2013) Neighborhood socioeconomic disadvantage and mortality after stroke. Neurology 80:520-7
Vickrey, Barbara G; Brott, Thomas G; Koroshetz, Walter J et al. (2013) Research priority setting: a summary of the 2012 NINDS Stroke Planning Meeting Report. Stroke 44:2338-42