Our major goal is to advance diversity by creating a strong neuroscience center in Puerto Rico that will develop Hispanic American neuroscientists through a program that integrates research, graduate education, undergraduate engagement, and career guidance. Neuroscience research at Universidad Central del Caribe (UCC) has grown significantly over the last decade, and we are now are positioned to bring neuroscience at UCC to the next level, one defined by continued excellence in basic research, growth in translational research, collaborations with top mainland universities, multidisciplinary training of students from underrepresented minority groups, and fostering professional development in these individuals. At the core of this effort will be a state-of-the-art Institute for Neuroscience that integrates high performance in basic and translational research with educational programs and ongoing mentoring of students and young faculty. The specific objectives of our program are to: 1) increase diversity and develop excellence in neuroscience research in Puerto Rico, and 2) provide first-rate training in neuroscience research and career development guidance for faculty, graduate students, medical students, and undergraduates that are Hispanic Americans and often from disadvantaged backgrounds. Our research program is focused on the mechanisms of neuronal plasticity and neuroprotection against stroke, thus creating a bridge between basic and translational research on neuronal mechanisms. The proposed research program creates a multi-university crossdisciplinary network of neuroscientists that will facilitate mentoring relationships, amplify scientific synergism, and at the same time broaden the research focus of every member of the group as well as bridge basic and translational research. Building on a foundation grounded in an interdisciplinary, collaborative research network and research program addressing health-related problems through basic and translational neuroscience, we will develop a comprehensive training and mentoring program that serves both faculty and students. By creating a strong and efficient training and mentoring center in neuroscience on the Island of Puerto Rico that serves Hispanic Americans, the proposed program has the potential to significantly promote workforce diversity in the U.S.

Public Health Relevance

Developing highly skilled neuroscience researchers capable of advancing our understanding of diseases that are priorities for NINDS is critical for improving public health. There is a simultaneous need to increase the diversity of the neuroscience workforce in the United States to assure future global competitiveness. To address both these needs, a training program will be implemented in Puerto Rico to prepare Hispanic American faculty, graduate students, and undergraduates to become outstanding neuroscientists.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZNS1-SRB-N)
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Universidad Central Del Caribe
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Astorga, César; Jorquera, Ramón A; Ramírez, Mauricio et al. (2016) Presynaptic DLG regulates synaptic function through the localization of voltage-activated Ca(2+) Channels. Sci Rep 6:32132
Bykhovskaia, Maria (2015) Calcium binding promotes conformational flexibility of the neuronal Ca(2+) sensor synaptotagmin. Biophys J 108:2507-20
Berríos, Verónica O; Boukli, Nawal M; Rodriguez, Jose W et al. (2015) Paraoxon and Pyridostigmine Interfere with Neural Stem Cell Differentiation. Neurochem Res 40:2091-101
Liu, Tianshu; Singh, Pankaj; Jenkins, James T et al. (2015) A continuum model of docking of synaptic vesicle to plasma membrane. J R Soc Interface 12:20141119
Vélez-Carrasco, Wanda; Green, Carol E; Catz, Paul et al. (2015) Pharmacokinetics and Metabolism of 4R-Cembranoid. PLoS One 10:e0121540
Fortoul, Nicole; Singh, Pankaj; Hui, Chung-Yuen et al. (2015) Coarse-Grained Model of SNARE-Mediated Docking. Biophys J 108:2258-69
Martins, A H; Hu, J; Xu, Z et al. (2015) Neuroprotective activity of (1S,2E,4R,6R,-7E,11E)-2,7,11-cembratriene-4,6-diol (4R) in vitro and in vivo in rodent models of brain ischemia. Neuroscience 291:250-9
Ferchmin, P A; Pérez, Dinely; Cuadrado, Brenda L et al. (2015) Neuroprotection Against Diisopropylfluorophosphate in Acute Hippocampal Slices. Neurochem Res 40:2143-51
Ferchmin, P A; Andino, Myrna; Reyes Salaman, Rebeca et al. (2014) 4R-cembranoid protects against diisopropylfluorophosphate-mediated neurodegeneration. Neurotoxicology 44:80-90
Vasin, Alexander; Zueva, Lidia; Torrez, Carol et al. (2014) Synapsin regulates activity-dependent outgrowth of synaptic boutons at the Drosophila neuromuscular junction. J Neurosci 34:10554-63

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