The Developmental Synaptopathies Consortium (DSC) Administrative Unit will facilitate the collaboration and communication of clinical research in the rare diseases of TSC, PTEN and PMS across the ten participating sites. The Administrative Unit will ensure collaboration among Project Leaders, Principal Investigators, and site study staff for the longitudinal research in each of the three identified diseases, the training component, the clinical pilot studies, and the access to information related to the rare diseases for basic and clinical researchers, other health professionals and the public.

Public Health Relevance

The Administrative Unit provides the key framework for success collaboration amongst the investigators involved in this Consortium. The Unit will ensure that research is conducted uniformly across all sites. It will be responsible for creating budgets and allocating funds in a rational, fair and appropriate manner. It will create policies and procedures related to all aspects of the studies, including the pilot projects and the training component.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZTR1)
Program Officer
Mamounas, Laura
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Children's Hospital Boston
United States
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Im, Kiho; Ahtam, Banu; Haehn, Daniel et al. (2016) Altered Structural Brain Networks in Tuberous Sclerosis Complex. Cereb Cortex 26:2046-58
Ebrahimi-Fakhari, Darius; Saffari, Afshin; Wahlster, Lara et al. (2016) Congenital disorders of autophagy: an emerging novel class of inborn errors of neuro-metabolism. Brain 139:317-37
Dölen, Gül; Sahin, Mustafa (2016) Editorial: Essential Pathways and Circuits of Autism Pathogenesis. Front Neurosci 10:182
Scherrer, Benoit; Schwartzman, Armin; Taquet, Maxime et al. (2016) Characterizing brain tissue by assessment of the distribution of anisotropic microstructural environments in diffusion-compartment imaging (DIAMOND). Magn Reson Med 76:963-77
Frazier, Thomas W; Klingemier, Eric W; Beukemann, Mary et al. (2016) Development of an Objective Autism Risk Index Using Remote Eye Tracking. J Am Acad Child Adolesc Psychiatry 55:301-9
Sahin, Mustafa; Henske, Elizabeth P; Manning, Brendan D et al. (2016) Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference. Pediatr Neurol 60:1-12
Marami, Bahram; Scherrer, Benoit; Afacan, Onur et al. (2016) Motion-Robust Diffusion-Weighted Brain MRI Reconstruction Through Slice-Level Registration-Based Motion Tracking. IEEE Trans Med Imaging 35:2258-2269
Costales, Jesse; Kolevzon, Alexander (2016) The therapeutic potential of insulin-like growth factor-1 in central nervous system disorders. Neurosci Biobehav Rev 63:207-22
Taquet, Maxime; Scherrer, Benoit; Boumal, Nicolas et al. (2015) Improved fidelity of brain microstructure mapping from single-shell diffusion MRI. Med Image Anal 26:268-86
He, Xin; Thacker, Stetson; Romigh, Todd et al. (2015) Cytoplasm-predominant Pten associates with increased region-specific brain tyrosine hydroxylase and dopamine D2 receptors in mouse model with autistic traits. Mol Autism 6:63

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