? PUBLIC ENGAGEMENT CORE - EPIBIOS4RX The overarching goal of the Public Engagement Core is to actively engage voluntary organizations with the EpiBioS4Rx CWOW in public outreach and knowledge transfer for the development of effective strategies to successfully design and complete clinical research studies, including future trials of prevention therapy in epilepsy. The scientific premise of EpiBioS4Rx is: Epileptogenesis after traumatic brain injury (TBI) can be prevented with specific treatments; the identification of relevant biomarkers and performance of rigorous preclinical trials will permit the future design and performance of economically feasible full-scale clinical trials of antiepileptogenic therapies. The Public Engagement Core aims at creating a consortium of consumers and consumer organizations, scientific (professional) societies, health organizations and EpiBioS4Rx investigators to assist with public outreach and facilitate interactions and communication among our partners to effectively promote participatory action research. To achieve a solid grounding between concept, practice and action, we have recruited several constituencies in the planning and decision making processes. A unique feature of our proposed patient engagement program is the preventative nature of this study. We are planning to involve patients who have suffered TBI and are considered to be at risk of developing epilepsy, but do not currently have the condition. Therefore, we are seeking patient involvement in the development of recruitment strategies for clinical trials for epileptogenesis, to which the patients may or may not develop. Subsequently, the Public Engagement Core will involve both consumers (actual patients and their caregivers) and consumer groups in identifying effective strategies to design large-scale interventional clinical trials of antiepileptogenic therapies in TBI and committed to effective recruitment and retention. The ultimate objective of the Core is to create a universal shared resource for epilepsy involving consumers and consumer organizations that could be used to design and execute large-scale intervention studies.

Public Health Relevance

? EPIBIOS4RX PUBLIC ENGAGEMENT CORE The Public Engagement Core is designed to actively engage voluntary organizations with the EpiBioS4Rx CWOW in public outreach and knowledge transfer for the development of effective strategies to successfully design and complete rigorous multicenter clinical research studies, including future cost effective full-scale clinical trials of epilepsy prevention therapies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54NS100064-03
Application #
9650651
Study Section
Special Emphasis Panel (ZNS1)
Project Start
Project End
Budget Start
2018-12-01
Budget End
2019-11-30
Support Year
3
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Southern California
Department
Type
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
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Barker-Haliski, Melissa L; Löscher, Wolfgang; White, H Steve et al. (2017) Neuroinflammation in epileptogenesis: Insights and translational perspectives from new models of epilepsy. Epilepsia 58 Suppl 3:39-47
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Shandra, Oleksii; Moshé, Solomon L; Galanopoulou, Aristea S (2017) Inflammation in Epileptic Encephalopathies. Adv Protein Chem Struct Biol 108:59-84
Harte-Hargrove, Lauren C; French, Jacqueline A; Pitkänen, Asla et al. (2017) Common data elements for preclinical epilepsy research: Standards for data collection and reporting. A TASK3 report of the AES/ILAE Translational Task Force of the ILAE. Epilepsia 58 Suppl 4:78-86
Kadam, Shilpa D; D'Ambrosio, Raimondo; Duveau, Venceslas et al. (2017) Methodological standards and interpretation of video-electroencephalography in adult control rodents. A TASK1-WG1 report of the AES/ILAE Translational Task Force of the ILAE. Epilepsia 58 Suppl 4:10-27
Hernan, Amanda E; Schevon, Catherine A; Worrell, Gregory A et al. (2017) Methodological standards and functional correlates of depth in vivo electrophysiological recordings in control rodents. A TASK1-WG3 report of the AES/ILAE Translational Task Force of the ILAE. Epilepsia 58 Suppl 4:28-39
Fisher, Robert S; Cross, J Helen; French, Jacqueline A et al. (2017) Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 58:522-530
Nariai, Hiroki; Beal, Jules; Galanopoulou, Aristea S et al. (2017) Scalp EEG Ictal gamma and beta activity during infantile spasms: Evidence of focality. Epilepsia 58:882-892

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