This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Since the beginning of RMATRIX the Research Design and Biostatistics function has focused on continuing support for ongoing studies, extending the range of investigators supported, offering courses and other educational opportunities, and building its functional capacity. To build capacity the function has recruited three Ph.D. biostatisticians who will be joining RMATRIX in the coming months. Dr. John Chen will be coming from Stonybrook in July to lead the biostatistics core. Projects ongoing at the start of RMATRIX have continued to receive support, and a wider range of investigators with new projects have received help upon request. The Research Design and Biostatistics function has provided assistance with seven research proposals submitted for federal funding. The function has performed data analysis for research studies related to all six of the RMATIX health initiative priorities. Investigators have received support from across the University of Hawaii: from the School of Medicine, the School of Nursing, the Office of Public Health, the Department of Human Nutrition, and the School of Pharmacy. The Research Design &Biostatistics function has supported the Multidisciplinary Research, Education, Training and Career development function by offering introductory and advanced biostatistics courses to students pursuing Master's and Ph.D. degrees in clinical research. Students also receive help with design and analysis issues related to their research projects. In addition, a new, non-degree course is being developed for a lay-audience on comparative effectiveness research. With increasing capacity the Research Design and Biostatistics function will expand its research support and educational activities in the future. Research Design and Biostatistic

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54RR026136-02
Application #
8364969
Study Section
Special Emphasis Panel (ZRR1-RI-1 (02))
Project Start
2011-07-01
Project End
2012-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
2
Fiscal Year
2011
Total Cost
$379,664
Indirect Cost
Name
University of Hawaii
Department
Type
Schools of Medicine
DUNS #
965088057
City
Honolulu
State
HI
Country
United States
Zip Code
96822
McIntosh, Roger C; Chow, Dominic C; Lum, Corey J et al. (2017) Reduced functional connectivity between ventromedial prefrontal cortex and insula relates to longer corrected QT interval in HIV+ and HIV- individuals. Clin Neurophysiol 128:1839-1850
Chuang, Eleanore; Lim, Eunjung; Milne, Cris et al. (2016) Human Papillomavirus at Multiple Sites Associated with Anal Squamous Intraepithelial Lesions in HIV-Seropositive Individuals. Ann Clin Cytol Pathol 2:
Kallianpur, Kalpana J; Gerschenson, Mariana; Mitchell, Brooks I et al. (2016) Oxidative mitochondrial DNA damage in peripheral blood mononuclear cells is associated with reduced volumes of hippocampus and subcortical gray matter in chronically HIV-infected patients. Mitochondrion 28:8-15
Chow, Dominic; Kohorn, Lindsay; Souza, Scott et al. (2016) Atazanavir use and carotid intima media thickness progression in HIV: potential influence of bilirubin. AIDS 30:672-4
Eze, Nwando; Smith, Lynne M; LaGasse, Linda L et al. (2016) School-Aged Outcomes following Prenatal Methamphetamine Exposure: 7.5-Year Follow-Up from the Infant Development, Environment, and Lifestyle Study. J Pediatr 170:34-8.e1
Gangcuangco, Louie Mar A; Kohorn, Lindsay B; Chow, Dominic C et al. (2016) High 25-hydroxyvitamin D is associated with unexpectedly high plasma inflammatory markers in HIV patients on antiretroviral therapy. Medicine (Baltimore) 95:e5270
Munger, Alana M; Chow, Dominic C; Playford, Martin P et al. (2015) Characterization of lipid composition and high-density lipoprotein function in HIV-infected individuals on stable antiretroviral regimens. AIDS Res Hum Retroviruses 31:221-8
Chow, Dominic; Young, Rebekah; Valcour, Nicole et al. (2015) HIV and coronary artery calcium score: comparison of the Hawaii Aging with HIV Cardiovascular Study and Multi-Ethnic Study of Atherosclerosis (MESA) cohorts. HIV Clin Trials 16:130-8
Parikh, Nisha I; Gerschenson, Mariana; Bennett, Kara et al. (2015) Lipoprotein concentration, particle number, size and cholesterol efflux capacity are associated with mitochondrial oxidative stress and function in an HIV positive cohort. Atherosclerosis 239:50-4
Shikuma, Cecilia M; Bennett, Kara; Ananworanich, Jintanat et al. (2015) Distal leg epidermal nerve fiber density as a surrogate marker of HIV-associated sensory neuropathy risk: risk factors and change following initial antiretroviral therapy. J Neurovirol 21:525-34

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