This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Cardiovascular Disease (CVD) and related disorders remain the leading cause of death in the nation1. Hypovitaminosis D has been linked not only to several cardiovascular (CV) risk factors including hypertension, diabetes, obesity2,3, but also to increased rates of CVD4,5,6. Thus, hypovitaminosis D presents a common pathway for a select subgroup with a clustering of CV risk factors in a profile that is predominant among ethnic minorities. Indeed, hypovitaminosis D is highly prevalent with an estimated 55% of the US adult population having levels at or below 30 ng/ml, and over 80% of African Americans having suboptimal values.7 A large body of evidence supports the premise that therapeutic agents that have salutary effects on vascular function, often translate into therapeutic benefits on 'harder'clinical endpoints such as adverse CV events and mortality. Exploring the potential vascular effects of vitamin D repletion presents a unique opportunity to examine both clinical outcomes and specific mechanistic pathways of a potentially modifiable intervention that could result in significant impact at a public health level. Thus, we propose a twelve week randomized doubleblind, placebo controlled pilot trial to assess the effect on vascular function and CV risk factors of 100,000 IU Vitamin D3 given every 4 weeks to overweight, hypertensive African-Americans with hypovitaminosis D. To our knowledge, the proposed project is the first to assess the effect of 'high-dose'Vitamin D3 administration on vascular function. We believe this study is also the first to examine the impact at a molecular level of Vitamin D3 repletion on the key mediators of cardio-metabolic pathways in humans. If our study results support our working hypothesis, we will be positioned to propose a larger scale study to detect a therapeutic effect on more definitive, clinical cardiovascular endpoints across a more diverse population. Hypothesis: Hypovitaminosis D activates select vasconstrictive and hypertrophic mediators that lead to endothelial dysfunction, elevated blood pressure and CVD;and Vitamin D3 repletion (using evidenced-based repletion strategies), in comparison to placebo, will ameliorate these abnormalities.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54RR026138-03
Application #
8359856
Study Section
Special Emphasis Panel (ZRR1-RI-8 (01))
Project Start
2011-07-01
Project End
2012-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
3
Fiscal Year
2011
Total Cost
$72,808
Indirect Cost
Name
Charles R. Drew University of Medicine & Science
Department
Type
Other Domestic Higher Education
DUNS #
785877408
City
Los Angeles
State
CA
Country
United States
Zip Code
90059
Kermah, Dulcie; Shaheen, Magda; Pan, Deyu et al. (2017) Association between secondhand smoke and obesity and glucose abnormalities: data from the National Health and Nutrition Examination Survey (NHANES 1999-2010). BMJ Open Diabetes Res Care 5:e000324
Paz, Sylvia H; Jones, Loretta; Calderón, José L et al. (2017) Readability and Comprehension of the Geriatric Depression Scale and PROMIS(®) Physical Function Items in Older African Americans and Latinos. Patient 10:117-131
Badr El-Din, Nariman K; Abdel Fattah, Salma M; Pan, Deyu et al. (2016) Chemopreventive Activity of MGN-3/Biobran Against Chemical Induction of Glandular Stomach Carcinogenesis in Rats and Its Apoptotic Effect in Gastric Cancer Cells. Integr Cancer Ther 15:NP26-NP34
Ghoneum, Mamdooh; Felo, Nouran (2015) Selective induction of apoptosis in human gastric cancer cells by Lactobacillus kefiri (PFT), a novel kefir product. Oncol Rep 34:1659-66
Ogunyemi, Omolola; Kermah, Dulcie (2015) Machine Learning Approaches for Detecting Diabetic Retinopathy from Clinical and Public Health Records. AMIA Annu Symp Proc 2015:983-90
Ghoneum, Mamdooh H; Badr El-Din, Nariman K; Abdel Fattah, Salma M et al. (2015) Hydroferrate fluid, MRN-100, provides protection against chemical-induced gastric and esophageal cancer in Wistar rats. Int J Biol Sci 11:295-303
Sinha-Hikim, I; Duran, P; Shen, R et al. (2015) Effect of long term vitamin D supplementation on biomarkers of inflammation in Latino and African-American subjects with pre-diabetes and hypovitaminosis D. Horm Metab Res 47:280-3
George, Sheba; Duran, Nelida; Norris, Keith (2014) A systematic review of barriers and facilitators to minority research participation among African Americans, Latinos, Asian Americans, and Pacific Islanders. Am J Public Health 104:e16-31
Davidson, Mayer B (2014) Self-mixed/split insulin regimen: a serious omission in the ADA/EASD position statement. Diabetes Care 37:3-4
Davidson, Mayer B; Pan, Deyu (2014) Epidemiological ramifications of diagnosing diabetes with HbA1c levels. J Diabetes Complications 28:464-9

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