Through its four integrated service divisions, the Facility Maintenance and Operafion Core (FAC-OPS) provides high containment operational management monitoring and oversight;routine facilities preventive maintenance and upkeep of the GNL physical plant that supports the entire facility including the high containment space and a preventative maintenance plan for all BSL4 equipment and systems;non-routine emergency repairs of BSL4 equipment and systems;and specialized training for facilities personnel working in and around BSL4 space and associated building systems. This core ensures continuous scientific support by combining management of base science support and high containment operafional systems thus better maintaining synchrony with scientific program needs. Funcfional safety and security is ensured by independent oversight by autonomous entifies from other cores that have supervisory responsibilifies (biosafety, security, GMP&GLP compliance). The scientific, engineering and biosafety training acfivifies within the GNL are interiinked with a succession of training experiences at increasing levels of biosafety for individuals with no previous experience within biocontainment. The progression of scientists and support staff through these levels is an important funcfion of the training mission of the GNL which incorporates all levels of biosafety including BSL4. The amalgamafion of science support, biocontainment and engineering services gives scientific and engineering staff increased opportunities to understand the integrated nature of such a facility and the importance of communicafion within the operafional elements.

Public Health Relevance

The Facility Maintenance and Operation Core provides high containment management and oversight, preventive maintenance and upkeep ofthe GNL physical plant, and specialized training for facilities personnel working in and around the BSL4 labs and associated systems. Operations and maintenance is closely coordinated with scientific program needs to ensure optimum support and maximum productivity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
National Biocontainment Laboratory Operation Cooperative Agreement (UC7)
Project #
5UC7AI094660-03
Application #
8496690
Study Section
Special Emphasis Panel (ZAI1-PRJ-M)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
3
Fiscal Year
2013
Total Cost
$5,990,859
Indirect Cost
$1,867,179
Name
University of Texas Medical Br Galveston
Department
Type
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555
Patterson, Michael; Seregin, Alexey; Huang, Cheng et al. (2014) Rescue of a recombinant Machupo virus from cloned cDNAs and in vivo characterization in interferon (**/ýý) receptor double knockout mice. J Virol 88:1914-23
Thangamani, Saravanan; Bente, Dennis (2014) Establishing protocols for tick containment at Biosafety Level 4. Pathog Dis 71:282-5
Hermance, Meghan E; Thangamani, Saravanan (2014) Proinflammatory cytokines and chemokines at the skin interface during Powassan virus transmission. J Invest Dermatol 134:2280-3
Yun, Nadezhda E; Seregin, Alexey V; Walker, David H et al. (2013) Mice lacking functional STAT1 are highly susceptible to lethal infection with Lassa virus. J Virol 87:10908-11