This revised application for a Clinical and Translational Science Award (CTSA) would support the continued development of the Los Angeles Basin Clinical and Translational Science Institute (CTSI). Our vision is to improve health of the diverse and underserved population of urban Los Angeles and, in doing so, to gain knowledge that we can share with others to improve health in urban settings and megacities across the globe. In pursuit of that vision, we have established a unique partnership of leading academic, clinical and community health organizations in the urban heart of Los Angeles. We are transforming this partnership into a preeminent clinical and translational science institute focused on better heath for diverse, urban communities. We have established four main goals for the CTSI: build on many independent strengths to create an integrated academic home that places high priority on clinical and translational science; create new translational research teams and conduct projects that leverage our unique populations and partnerships to address the best scientific opportunities and most important health priorities of our local communities; transform education and training to create a cadre of people with a major career focus on clinical and translational research; and implement and disseminate what we learn to improve health in our local communities and advance translational research through regional and national networks and collaborations. To achieve these goals, we have assembled an exceptional leadership team that is creating through the CTSI: outstanding resources for active development of new research projects and teams, a robust infrastructure to promote and support basic, clinical and community research, cutting edge methodologies for data acquisition, integration, management and analysis; integrated training of basic, clinical and community researchers using distance education and a focus on research for the diverse communities; a novel approach to dissemination of our findings using professional communications expertise; and a professional evaluation group to track and evaluate our progress and impact. Using $3.3M of institutional support, we have already made significant progress in transforming our local environment to a home that highly values clinical and translational research. We demonstrate strong ability to generate and support exciting new research, from the bench to our communities. With a CTSA and a pledge of $18.7M of institutional support over five years, we will expand to a fully functional institute that will have a have a major impact to improve urban health and advance the discipline of clinical and translational research.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Linked Specialized Center Cooperative Agreement (UL1)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-CR-3 (01))
Program Officer
Joskow, Renee
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Southern California
Internal Medicine/Medicine
Schools of Medicine
Los Angeles
United States
Zip Code
Writing Committee for the Type 1 Diabetes TrialNet Oral Insulin Study Group; Krischer, Jeffrey P; Schatz, Desmond A et al. (2017) Effect of Oral Insulin on Prevention of Diabetes in Relatives of Patients With Type 1 Diabetes: A Randomized Clinical Trial. JAMA 318:1891-1902
Briere, John; Dias, Colin P; Semple, Randye J et al. (2017) Acute Stress Symptoms in Seriously Injured Patients: Precipitating Versus Cumulative Trauma and the Contribution of Peritraumatic Distress. J Trauma Stress 30:381-388
Paquette, N; Shi, J; Wang, Y et al. (2017) Ventricular shape and relative position abnormalities in preterm neonates. Neuroimage Clin 15:483-493
Fini, M Elizabeth; Schwartz, Stephen G; Gao, Xiaoyi et al. (2017) Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine. Prog Retin Eye Res 56:58-83
Semple, Randye J; Droutman, Vita; Reid, Brittany Ann (2017) MINDFULNESS GOES TO SCHOOL: THINGS LEARNED (SO FAR) FROM RESEARCH AND REAL-WORLD EXPERIENCES. Psychol Sch 54:29-52
Patino, Cecilia M; Kubicek, Katrina; Robles, Marisela et al. (2017) The Community Mentorship Program: Providing Community-Engagement Opportunities for Early-Stage Clinical and Translational Scientists to Facilitate Research Translation. Acad Med 92:209-213
Bowdish, Michael E; Hui, Dawn S; Cleveland, John D et al. (2016) A comparison of aortic valve replacement via an anterior right minithoracotomy with standard sternotomy: a propensity score analysis of 492 patients. Eur J Cardiothorac Surg 49:456-63
Kim, Mimi S; Dao-Tran, Anh; Davidowitz, Elana et al. (2016) Carotid Intima-Media Thickness Is Associated with Increased Androgens in Adolescents and Young Adults with Classical Congenital Adrenal Hyperplasia. Horm Res Paediatr 85:242-9
Reuter, Katja; Ukpolo, Francis; Ward, Edward et al. (2016) Trial Promoter: A Web-Based Tool for Boosting the Promotion of Clinical Research Through Social Media. J Med Internet Res 18:e144
Despanie, Jordan; Dhandhukia, Jugal P; Hamm-Alvarez, Sarah F et al. (2016) Elastin-like polypeptides: Therapeutic applications for an emerging class of nanomedicines. J Control Release 240:93-108

Showing the most recent 10 out of 138 publications