Entering its fifth year, the Johns Hopkins Institute for Clinical and Translational Research (ICTR) is dedicated to creating a new model for conducting clinical and translational research throughout the Johns Hopkins University, by addressing critical obstacles that impede the progress of basic science discoveries to the clinic, and clinical discoveries into the community. By encouraging and catalyzing change, the ICTR seeks to lower barriers between scientific disciplines, foster collaboration, and. provide creative, innovative approaches to the solution of complex medical problems. Through the national consortium of CTSA institutions, the ICTR also participates in the advancement of Clinical and Translational Research as an academic discipline. The ICTR offers a wide variety of consulting, educational, training, infrastructure and support services to any and all members ofthe Johns Hopkins research community who are currently preparing or executing a study. The ICTR supports adult inpatient/outpatient, child inpatient/outpatient clinical reseach units at both the Johns Hopkins Hospital and Johns Hopkins Bayview Medical Center. The ICTR provides support for investigators from early Tl translation (Drug Development, Geneomics and Proteomics Translational Cores) to final phases of T2 translation (Community Engagement and Knowledge Implementation Programs). Protecting human research participants in the broadest sense is essential to the mission of translational research so the ICTR supports research participant advocates and regulatory knowledge program that has the primary role of research ethics training at Johns Hopkins. Delays in getting pilot funding is a huge barrier to accelerating the pace of translational research. In response we have created an Accelerated Translational Incubator Program (ATIP) which funds translational teams for a milestone driven, project managed one year period of time. The ICTR has created the Johns Hopkins Clinical Research Network (JHCRN) with 11 hospitals (including 6 non Johns Hopkins Hospitals). The JHCRN includes written agreements to improve the efficiency of study startup. Finally the ICTR has a strong commitment to training the new generation of researchers through comprehensive programs.

Public Health Relevance

; By identifying and overcoming barriers in the translational pathway, increasing scientific collaboration, providing consultative services, clinical infrastructure, and technology cores that bridge the gap between the laboratory and the clinic, the ICTR helps to speed the pace of scientific discovery, and bring effective therapies to the public, and improve the health of Americans.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
2UL1TR000424-06
Application #
8467130
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Brazhnik, Olga
Project Start
2012-09-04
Project End
2013-05-31
Budget Start
2012-09-04
Budget End
2013-05-31
Support Year
6
Fiscal Year
2012
Total Cost
$6,033,752
Indirect Cost
$1,215,398
Name
Johns Hopkins University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Drawz, Paul E; Alper, Arnold B; Anderson, Amanda H et al. (2016) Masked Hypertension and Elevated Nighttime Blood Pressure in CKD: Prevalence and Association with Target Organ Damage. Clin J Am Soc Nephrol 11:642-52
Denburg, Michelle R; Hoofnagle, Andrew N; Sayed, Samir et al. (2016) Comparison of Two ELISA Methods and Mass Spectrometry for Measurement of Vitamin D-Binding Protein: Implications for the Assessment of Bioavailable Vitamin D Concentrations Across Genotypes. J Bone Miner Res 31:1128-36
Lucas, Gregory M; Atta, Mohamed G; Fine, Derek M et al. (2016) HIV, Cocaine Use, and Hepatitis C Virus: A Triad of Nontraditional Risk Factors for Subclinical Cardiovascular Disease. Arterioscler Thromb Vasc Biol 36:2100-7
Nelson, J E; Handa, P; Aouizerat, B et al. (2016) Increased parenchymal damage and steatohepatitis in Caucasian non-alcoholic fatty liver disease patients with common IL1B and IL6 polymorphisms. Aliment Pharmacol Ther 44:1253-1264
Okafor, Chukwuemeka N; Cook, Robert L; Chen, Xinguang et al. (2016) Trajectories of Marijuana Use among HIV-seropositive and HIV-seronegative MSM in the Multicenter AIDS Cohort Study (MACS), 1984-2013. AIDS Behav :
Dinglas, Victor D; Hopkins, Ramona O; Wozniak, Amy W et al. (2016) One-year outcomes of rosuvastatin versus placebo in sepsis-associated acute respiratory distress syndrome: prospective follow-up of SAILS randomised trial. Thorax 71:401-10
Tangri, Navdeep; Grams, Morgan E; Levey, Andrew S et al. (2016) Multinational Assessment of Accuracy of Equations for Predicting Risk of Kidney Failure: A Meta-analysis. JAMA 315:164-74
Schwimmer, Jeffrey B; Lavine, Joel E; Wilson, Laura A et al. (2016) In Children With Nonalcoholic Fatty Liver Disease, Cysteamine Bitartrate Delayed Release Improves Liver Enzymes but Does Not Reduce Disease Activity Scores. Gastroenterology 151:1141-1154.e9
Mukerji, Shibani S; Locascio, Joseph J; Misra, Vikas et al. (2016) Lipid Profiles and APOE4 Allele Impact Midlife Cognitive Decline in HIV-Infected Men on Antiretroviral Therapy. Clin Infect Dis 63:1130-9
Amdur, Richard L; Feldman, Harold I; Gupta, Jayanta et al. (2016) Inflammation and Progression of CKD: The CRIC Study. Clin J Am Soc Nephrol 11:1546-56

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