The University of Chicago (UC) Institute for Translational Medicine (ITM) was created in 2007 to assemble, integrate, and create the intellectual, administrative, and physical resources required to catalyze research and research training in Clinical and Translational Science. Its ultimate goals are to train scientists and health care providers at UC and in our community to determine the molecular, genetic, pathophysiologic and social determinants of disease and disease predisposition in individuals;to test interventions directed toward those mechanisms;and to achieve these goals in a way that is rigorous, efficient, ethical, respectful of, and responsive to our community's needs and values. In its first 4 years, the ITM has capitalized on the outstanding intellectual and physical resources throughout the University and at ITM affiliate Institutions, Argonne National Laboratory, NorthShore University HealthSystem, Illinois Institute of Technology, and Access Community Health Network, and on substantial institutional and CTSA financial investments, to build the infrastructure for a transformative, energized, and self-improving home for clinical and translational research. The impact of the ITM has been greatest in 5 domains: 1) catalyzing the formation of multidisciplinary research teams;2) establishing a systematic, organized clinical and translational research infrastructure;3) engaging our community in research;4) training for careers in clinical and translational team science;and 5) impact on and contributions to the National CTSA Consortium. Building on these, we propose to expand research and training opportunities with five major initiatives: a new T1 Research and Technology Cluster;new Cores in Comparative Effectiveness Research and in Social, Environmental, and non-Biological Determinants of Health;a Personalizing Medicine initiative;a new Entrepreneurship Training and Support Program;and a Nurse-Scientist Training Program at new ITM affiliate Rush University. These programs, strengthened by community advice, engagement, partnership and participation, will ensure continued transformation of clinical and translational science at the University of Chicago and affiliates, on the South Side of Chicago, and beyond.
This program leverages the expertise of University of Chicago and affiliated investigators in a broad array of clinical and nonclinical fields to prepare the next generation of clinical and translational researchers to engage with our community partners to identify and prioritize a translational research agenda, and to address and reduce clinical health disparities in diverse adult and pediatric populations in our Community.
|Li, Yan; Andrade, Jorge (2017) DEApp: an interactive web interface for differential expression analysis of next generation sequence data. Source Code Biol Med 12:2|
|Biering, Scott B; Choi, Jayoung; Halstrom, Rachel A et al. (2017) Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases. Cell Host Microbe 22:74-85.e7|
|Siva, Shivi; Rubin, David T; Gulotta, George et al. (2017) Zinc Deficiency is Associated with Poor Clinical Outcomes in Patients with Inflammatory Bowel Disease. Inflamm Bowel Dis 23:152-157|
|Narayanamurthy, Vaishnavi; Sweetnam, John M; Denner, Darcy R et al. (2017) The metabolic footprint of the airway bacterial community in cystic fibrosis. Microbiome 5:67|
|Bunyak, Filiz; Shiraishi, Naru; Palaniappan, Kannappan et al. (2017) Development of semi-automatic procedure for detection and tracking of fiducial markers for orofacial kinematics during natural feeding. Conf Proc IEEE Eng Med Biol Soc 2017:580-583|
|Fan, Jiaming; Wei, Qiang; Liao, Junyi et al. (2017) Noncanonical Wnt signaling plays an important role in modulating canonical Wnt-regulated stemness, proliferation and terminal differentiation of hepatic progenitors. Oncotarget 8:27105-27119|
|Volerman, Anna; Ignoffo, Stacy; Hull, Ashley et al. (2017) Identification of students with asthma in Chicago schools: Missing the mark. Ann Allergy Asthma Immunol 118:739-740|
|Sample, Ashley; Zhao, Baozhong; Qiang, Lei et al. (2017) Adaptor protein p62 promotes skin tumor growth and metastasis and is induced by UVA radiation. J Biol Chem 292:14786-14795|
|Greeley, Siri Atma W; Zielinski, Mark C; Poudel, Ananta et al. (2017) Preservation of Reduced Numbers of Insulin-Positive Cells in Sulfonylurea-Unresponsive KCNJ11-Related Diabetes. J Clin Endocrinol Metab 102:1-5|
|Barrett, John C; Ulery, Bret D; Trent, Amanda et al. (2017) Modular Peptide Amphiphile Micelles Improving an Antibody-Mediated Immune Response to Group A Streptococcus. ACS Biomater Sci Eng 3:144-152|
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