This CTSA renewal application is built on the research infrastructure, training programs, and partnershipswe established in the first grant period, through creation ofthe Institute for Clinical and TranslationalSciences (ICTS), which brought about significant cultural and organizational changes at WashingtonUniversity in St. Louis and unprecedented collaboration between its partner institutions, including BJCHealthCare, Barnes-Jewish Hospital, St. Louis Children's Hospital, Saint Louis University, University ofMissouri - St. Louis, Southern Illinois University Edwardsville, Goldfarb School of Nursing at Barnes-JewishCollege, and the St. Louis College of Pharmacy. The overall goal of this application is to promote thetranslation of scientific discoveries into improvements in human health.
Our specific aims will transform our research support infrastructure to foster multidisciplinary clinical andtranslational research, expand and enhance clinical and translational research education programs, andpromote communication and collaborative research with regional and national partners. New initiativesinclude 3 new cross-cutting scientific themes where the resources of our ICTS are most likely to result inhigh-impact clinical research and its subsequent translation into clinical practice: translating the findings ofgenetic/genomic research into clinical research and practice, accelerating the development and evaluation ofnew therapeutics, and conducting comparative effectiveness and dissemination and implementationresearch to improve the transfer of research into practice. To ensure the continued success of the ICTS, WU has made significant commitments of space andfinancial support. Barnes-Jewish Hospital and St Louis Children's Hospital, our academic hospital partners,and BJC HealthCare, our affiliated health system, have also made substantial comhnitments to suppport theclinical and translational research activities ofthe ICTS. This institutionalsupport, combined with theprograms and collaborations we have started in the past four years, ensure that the ICTS will continue tomake outstanding contributions in clinical and translational science.

Public Health Relevance

The overall goal of this grant is to promote the translation of scientific discoveries into improvements inhuman health. Our proposal will improve clinical research infrastructure, services, and training programs inorder to speed the translation of new discoveries from the lab into humans, and to help implement the bestmedical evidence into clinical practice.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Linked Specialized Center Cooperative Agreement (UL1)
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Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Sawczuk, Andrea
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Washington University
Internal Medicine/Medicine
Schools of Medicine
Saint Louis
United States
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