This CTSA renewal application is built on the research infrastructure, training programs, and partnershipswe established in the first grant period, through creation ofthe Institute for Clinical and TranslationalSciences (ICTS), which brought about significant cultural and organizational changes at WashingtonUniversity in St. Louis and unprecedented collaboration between its partner institutions, including BJCHealthCare, Barnes-Jewish Hospital, St. Louis Children's Hospital, Saint Louis University, University ofMissouri - St. Louis, Southern Illinois University Edwardsville, Goldfarb School of Nursing at Barnes-JewishCollege, and the St. Louis College of Pharmacy. The overall goal of this application is to promote thetranslation of scientific discoveries into improvements in human health.
Our specific aims will transform our research support infrastructure to foster multidisciplinary clinical andtranslational research, expand and enhance clinical and translational research education programs, andpromote communication and collaborative research with regional and national partners. New initiativesinclude 3 new cross-cutting scientific themes where the resources of our ICTS are most likely to result inhigh-impact clinical research and its subsequent translation into clinical practice: translating the findings ofgenetic/genomic research into clinical research and practice, accelerating the development and evaluation ofnew therapeutics, and conducting comparative effectiveness and dissemination and implementationresearch to improve the transfer of research into practice. To ensure the continued success of the ICTS, WU has made significant commitments of space andfinancial support. Barnes-Jewish Hospital and St Louis Children's Hospital, our academic hospital partners,and BJC HealthCare, our affiliated health system, have also made substantial comhnitments to suppport theclinical and translational research activities ofthe ICTS. This institutionalsupport, combined with theprograms and collaborations we have started in the past four years, ensure that the ICTS will continue tomake outstanding contributions in clinical and translational science.
The overall goal of this grant is to promote the translation of scientific discoveries into improvements inhuman health. Our proposal will improve clinical research infrastructure, services, and training programs inorder to speed the translation of new discoveries from the lab into humans, and to help implement the bestmedical evidence into clinical practice.
|Tabak, Rachel G; Duggan, Katie; Smith, Carson et al. (2016) Assessing Capacity for Sustainability of Effective Programs and Policies in Local Health Departments. J Public Health Manag Pract 22:129-37|
|Ostendorf, Adam P; Hartman, Mary E; Friess, Stuart H (2016) Early Electroencephalographic Findings Correlate With Neurologic Outcome in Children Following Cardiac Arrest. Pediatr Crit Care Med 17:667-76|
|Abboud, Ramzi; Keller, Jesse; Slade, Michael et al. (2016) Severe Cytokine-Release Syndrome after T Cell-Replete Peripheral Blood Haploidentical Donor Transplantation Is Associated with Poor Survival and Anti-IL-6 Therapy Is Safe and Well Tolerated. Biol Blood Marrow Transplant 22:1851-60|
|Brier, Matthew R; McCarthy, John E; Benzinger, Tammie L S et al. (2016) Local and distributed PiB accumulation associated with development of preclinical Alzheimer's disease. Neurobiol Aging 38:104-11|
|Gierada, David S; Politte, David G; Zheng, Jie et al. (2016) Quantitative Computed Tomography Classification of Lung Nodules: Initial Comparison of 2- and 3-Dimensional Analysis. J Comput Assist Tomogr 40:589-95|
|Zuiani, Adam; Chen, Kevin; Schwarz, Megan C et al. (2016) A Library of Infectious Hepatitis C Viruses with Engineered Mutations in the E2 Gene Reveals Growth-Adaptive Mutations That Modulate Interactions with Scavenger Receptor Class B Type I. J Virol 90:10499-10512|
|Gruchalla, R S; Sampson, H A; Liu, A H et al. (2016) Effects of omalizumab on T lymphocyte function in inner-city children with asthma. Pediatr Allergy Immunol 27:328-31|
|Siegel, Joshua Sarfaty; Ramsey, Lenny E; Snyder, Abraham Z et al. (2016) Disruptions of network connectivity predict impairment in multiple behavioral domains after stroke. Proc Natl Acad Sci U S A 113:E4367-76|
|Stranges, Paul M; Vouri, Scott Martin (2016) Impact of resident research publication on early-career publication success. Am J Health Syst Pharm 73:895-900|
|Garbutt, Jane M; Patterson, DiTalliana; Gehlert, Sarah et al. (2016) Insights from parents can guide asthma care for urban, minority children. J Allergy Clin Immunol Pract :|
Showing the most recent 10 out of 1913 publications