This CTSA renewal application is built on the research infrastructure, training programs, and partnerships we established in the first grant period, through creation ofthe Institute for Clinical and Translational Sciences (ICTS), which brought about significant cultural and organizational changes at Washington University in St. Louis and unprecedented collaboration between its partner institutions, including BJC HealthCare, Barnes-Jewish Hospital, St. Louis Children's Hospital, Saint Louis University, University of Missouri - St. Louis, Southern Illinois University Edwardsville, Goldfarb School of Nursing at Barnes-Jewish College, and the St. Louis College of Pharmacy. The overall goal of this application is to promote the translation of scientific discoveries into improvements in human health.
Our specific aims will transform our research support infrastructure to foster multidisciplinary clinical and translational research, expand and enhance clinical and translational research education programs, and promote communication and collaborative research with regional and national partners. New initiatives include 3 new cross-cutting scientific themes where the resources of our ICTS are most likely to result in high-impact clinical research and its subsequent translation into clinical practice: translating the findings of genetic/genomic research into clinical research and practice, accelerating the development and evaluation of new therapeutics, and conducting comparative effectiveness and dissemination and implementation research to improve the transfer of research into practice. To ensure the continued success of the ICTS, WU has made significant commitments of space and financial support. Barnes-Jewish Hospital and St Louis Children's Hospital, our academic hospital partners, and BJC HealthCare, our affiliated health system, have also made substantial comhnitments to suppport the clinical and translational research activities ofthe ICTS. This institutionalsupport, combined with the programs and collaborations we have started in the past four years, ensure that the ICTS will continue to make outstanding contributions in clinical and translational science.
The overall goal of this grant is to promote the translation of scientific discoveries into improvements in human health. Our proposal will improve clinical research infrastructure, services, and training programs in order to speed the translation of new discoveries from the lab into humans, and to help implement the best medical evidence into clinical practice.
|Schroeder, Mark A; Rettig, Michael P; Lopez, Sandra et al. (2017) Mobilization of allogeneic peripheral blood stem cell donors with intravenous plerixafor mobilizes a unique graft. Blood 129:2680-2692|
|Foster, Erin R; McDaniel, Mark A; Rendell, Peter G (2017) Improving Prospective Memory in Persons With Parkinson Disease: A Randomized Controlled Trial. Neurorehabil Neural Repair 31:451-461|
|Miller-Thomas, Michelle M; Benzinger, Tammie L S (2017) Neurologic Applications of PET/MR Imaging. Magn Reson Imaging Clin N Am 25:297-313|
|Ablordeppey, Enyo A; Drewry, Anne M; Beyer, Alexander B et al. (2017) Diagnostic Accuracy of Central Venous Catheter Confirmation by Bedside Ultrasound Versus Chest Radiography in Critically Ill Patients: A Systematic Review and Meta-Analysis. Crit Care Med 45:715-724|
|Hiken, J F; McDonald, J I; Decker, K F et al. (2017) Epigenetic activation of the prostaglandin receptor EP4 promotes resistance to endocrine therapy for breast cancer. Oncogene 36:2319-2327|
|Iwata, Arifumi; Durai, Vivek; Tussiwand, Roxane et al. (2017) Quality of TCR signaling determined by differential affinities of enhancers for the composite BATF-IRF4 transcription factor complex. Nat Immunol 18:563-572|
|Zhao, Yue; Raichle, Marcus E; Wen, Jie et al. (2017) In vivo detection of microstructural correlates of brain pathology in preclinical and early Alzheimer Disease with magnetic resonance imaging. Neuroimage 148:296-304|
|Fuller, Brian M; Ferguson, Ian T; Mohr, Nicholas M et al. (2017) A Quasi-Experimental, Before-After Trial Examining the Impact of an Emergency Department Mechanical Ventilator Protocol on Clinical Outcomes and Lung-Protective Ventilation in Acute Respiratory Distress Syndrome. Crit Care Med 45:645-652|
|Spec, Andrej; Olsen, Margaret A; Raval, Krunal et al. (2017) Impact of Infectious Diseases Consultation on Mortality of Cryptococcal infection in Patients without HIV. Clin Infect Dis 64:558-564|
|Purtle, Jonathan; Lê-Scherban, Félice; Shattuck, Paul et al. (2017) An audience research study to disseminate evidence about comprehensive state mental health parity legislation to US State policymakers: protocol. Implement Sci 12:81|
Showing the most recent 10 out of 2377 publications