Cancer is the second leading cause of death in the United States after heart disease[1], anticipated to cause 570,000 deaths in 2012 alone. The most common cancers in the United States are lung, skin, breast, prostate, and colon cancer[2]. There have been tremendous advances in pre-clinical and clinical development of molecularly targeted therapies for these common cancers such as inhibitors of the epidermal growth factor receptor (EGFR), BRAF kinase, ERBB2 gene amplification (HER2), and androgen signaling pathway5(3-5]. In contrast to common cancers, rare cancers such as sarcomas present a challenge to the clinical oncologist since there are typically few retrospective studies available and little known about the molecular underpinnings. Thus, this clinical tumor sequencing study focuses on patients with these rare cancers to 1) provide clinically significant genomic sequencing data to patients and their doctors, and 2) expand the molecular taxonomy of these poorly defined cancers.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Research Project with Complex Structure Cooperative Agreement (UM1)
Project #
1UM1HG006508-01A1
Application #
8665542
Study Section
Special Emphasis Panel (ZHG1-HGR-N (J2))
Project Start
Project End
Budget Start
2013-07-19
Budget End
2014-05-31
Support Year
1
Fiscal Year
2013
Total Cost
$421,677
Indirect Cost
$150,502
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Gornick, Michele C; Scherer, Aaron M; Sutton, Erica J et al. (2016) Effect of Public Deliberation on Attitudes toward Return of Secondary Results in Genomic Sequencing. J Genet Couns :
Amendola, Laura M; Jarvik, Gail P; Leo, Michael C et al. (2016) Performance of ACMG-AMP Variant-Interpretation Guidelines among Nine Laboratories in the Clinical Sequencing Exploratory Research Consortium. Am J Hum Genet 98:1067-76
Everett, Jessica N; Mody, Rajen J; Stoffel, Elena M et al. (2016) Incorporating genetic counseling into clinical care for children and adolescents with cancer. Future Oncol 12:883-6
Rasmussen, Luke V; Overby, Casey L; Connolly, John et al. (2016) Practical considerations for implementing genomic information resources. Experiences from eMERGE and CSER. Appl Clin Inform 7:870-82
Roychowdhury, Sameek; Chinnaiyan, Arul M (2016) Translating cancer genomes and transcriptomes for precision oncology. CA Cancer J Clin 66:75-88
O'Daniel, Julianne M; McLaughlin, Heather M; Amendola, Laura M et al. (2016) A survey of current practices for genomic sequencing test interpretation and reporting processes in US laboratories. Genet Med :
Raymond, Victoria M; Gray, Stacy W; Roychowdhury, Sameek et al. (2016) Germline Findings in Tumor-Only Sequencing: Points to Consider for Clinicians and Laboratories. J Natl Cancer Inst 108:
Mehra, Rohit; Vats, Pankaj; Cieslik, Marcin et al. (2016) Biallelic Alteration and Dysregulation of the Hippo Pathway in Mucinous Tubular and Spindle Cell Carcinoma of the Kidney. Cancer Discov 6:1258-1266
Green, Robert C; Goddard, Katrina A B; Jarvik, Gail P et al. (2016) Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine. Am J Hum Genet 98:1051-66
Brothers, Kyle B; Holm, Ingrid A; Childerhose, Janet E et al. (2016) When Participants in Genomic Research Grow Up: Contact and Consent at the Age of Majority. J Pediatr 168:226-31.e1

Showing the most recent 10 out of 28 publications