Common, complex diseases constitute a major human heath burden. Rare genetic variants are an important component of disease risk and a full understanding of genetic architecture will require studies of hundreds of thousands - perhaps millions - of individuals. Study design, including ethnic diversity and pedigrees, and leveraging phenotypes proximal to the gene level will be critical for early success. Across three Discovery Projects, we will generate 50,000 whole genome sequences in well-phenotyped individuals to study disorders of the cardiovascular system, bone and metabolism. These projects will utilize Illumina HiSeq X instruments and the world-class analysis and informatics pipelines at Baylor College of Medicine's Human Genome Sequencing Center. Methods for investigating noncoding variation, including long-read haplotypes and structural variation, will be given particular attention throughout. The discovery projects will be followed by replication studies in even larger numbers, and a case-cohort strategy will aggregate these data as a prelude to a comprehensive experiment based on recruitment of patients via large health care networks. These prospective collections are a first step toward realizing precision medicine.

Public Health Relevance

The Genomic Architecture of Common Disease in Diverse Populations' will use the latest laboratory and computational technologies and already available sample sets to identify genetic risk factors underlying important human diseases. A study of whole genome sequences from more than 50,000 diverse individuals will be carried out to investigate heart, bone, obesity and other disorders. This will be a prelude to even larger studies that will systematically recruit patients from large health care networks, ultimately generating a comprehensive understanding of inherited risk of disease.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Research Project with Complex Structure Cooperative Agreement (UM1)
Project #
5UM1HG008898-02
Application #
9205527
Study Section
Special Emphasis Panel (ZHG1)
Program Officer
Felsenfeld, Adam
Project Start
2016-01-14
Project End
2019-11-30
Budget Start
2016-12-01
Budget End
2017-11-30
Support Year
2
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Genetics
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030