OppNet is a trans-NIH initiative that funds basic behavioral and social science research projects that build the collective body of knowledge about the complex factors that affect individuals, our communities and our environments. Results from this kind of research inform new approaches to ensure adherence, increase adoption of healthier practices, and reduce risky behaviors. All 24 NIH Institutes and Centers that fund research and four Program Offices within the NIH Office of the Director DPCPSI co-fund and co-manage OppNet. All OppNet initiatives invite investigators to propose innovative research that will advance a targeted domain of basic social and behavioral sciences and produce knowledge and/or tools of potential relevance to multiple domains of health- and lifecourse-related research. Applicants should understand that the NIH Institute or Center (IC) that made this FOA available to the public is not necessarily the NIH IC that ultimately will manage a funded OppNet project. Instead, OppNet assigns funding and project management of meritorious applications to the NIH IC whose scientific mission most closely corresponds to that of the proposed research project.