Abstract

During the past year, our research has continued its investigations of central nervous system (CNS) serotonin correlates of PET activity. A new study was initiated that was designed to assess serotonin correlates of intrinsic tolerance in alcohol naive rhesus macaques. To assess the role of serotonin functioning on excessive alcohol consumption and the related high levels of aggression, alcohol naive rhesus macaque subjects were given identical doses of IV alcohol and rated for levels of intoxication. Result showed that there was a nearly significant positive correlation between levels of intoxication and CSF 5-HIAA concentrations. Following the ratings for intoxication, an experimenter blind to the subjects' intoxication level and CSF 5-HIAA concentrations entered the room and rates of aggression by the subjects to the experimenter were recorded. Subjects with lower intoxication levels and low CSF 5-HIAA were more likely to aggress at the experimenter.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Intramural Research (Z01)
Project #
1Z01AA000077-02
Application #
5200232
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
National Institute on Alcohol Abuse and Alcoholism
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Shannon, Courtney; Schwandt, Melanie L; Champoux, Maribeth et al. (2005) Maternal absence and stability of individual differences in CSF 5-HIAA concentrations in rhesus monkey infants. Am J Psychiatry 162:1658-64
Maestripieri, Dario; Lindell, Stephen G; Ayala, Alejandro et al. (2005) Neurobiological characteristics of rhesus macaque abusive mothers and their relation to social and maternal behavior. Neurosci Biobehav Rev 29:51-7
Angeloni, Stephen V; Glynn, Nicole; Ambrosini, Grazia et al. (2004) Characterization of the rhesus monkey ghrelin gene and factors influencing ghrelin gene expression and fasting plasma levels. Endocrinology 145:2197-205
Barr, Christina S; Newman, Timothy K; Schwandt, Melanie et al. (2004) Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques. Proc Natl Acad Sci U S A 101:12358-63
Ayala, Alejandro R; Pushkas, Judy; Higley, J Dee et al. (2004) Behavioral, adrenal, and sympathetic responses to long-term administration of an oral corticotropin-releasing hormone receptor antagonist in a primate stress paradigm. J Clin Endocrinol Metab 89:5729-37
Barr, C S; Newman, T K; Lindell, S et al. (2004) Early experience and sex interact to influence limbic-hypothalamic-pituitary-adrenal-axis function after acute alcohol administration in rhesus macaques (Macaca mulatta). Alcohol Clin Exp Res 28:1114-9
Barr, Christina S; Newman, Timothy K; Shannon, Courtney et al. (2004) Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques. Biol Psychiatry 55:733-8
Gustavsson, Gunnar; Traskman-Bendz, Lil; Higley, J Dee et al. (2003) CSF testosterone in 43 male suicide attempters. Eur Neuropsychopharmacol 13:105-9
Bastian, Meredith L; Sponberg, Anne C; Sponberg, Anne C et al. (2003) Long-term effects of infant rearing condition on the acquisition of dominance rank in juvenile and adult rhesus macaques (Macaca mulatta). Dev Psychobiol 42:44-51
Heinz, A; Schafer, M; Higley, J D et al. (2003) Neurobiological correlates of the disposition and maintenance of alcoholism. Pharmacopsychiatry 36 Suppl 3:S255-8

Showing the most recent 10 out of 17 publications