Abstract

Innate immunity is the first line of defense designed to protect the host from invading pathogens, including HIV. LIR investigators have previously demonstrated that natural killer (NK) cells, an important component of the innate immune response, produced a significant quantity of CC-chemokines that are known to suppress HIV replication through a non-cytolytic mechanism. LIR investigators have analyzed the ability of NK cells to suppress HIV replication from CD4+ T cells of HIV-infected individuals in vitro. Data suggest that the NK-mediated suppression can be potent and that it is related to the stage of HIV infection as well as the level of HIV plasma viremia. The study has revealed that HIV viremia impairs the ability of NK cells to scerete CC-chemokines and alters the expression of various inhibitory and chemokine receptors expressed on NK cells. Future studies will focus on elucidating the mechanisms of the suppression of HIV replication by NK cells, and the effect of HIV and HIV envelopes on the function of NK cells in vitro.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000886-02
Application #
6669886
Study Section
(LIR)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Kottilil, Shyam; Yan, Michael Y; Reitano, Kristin N et al. (2009) Human immunodeficiency virus and hepatitis C infections induce distinct immunologic imprints in peripheral mononuclear cells. Hepatology 50:34-45
Chun, Tae-Wook; Nickle, David C; Justement, Jesse S et al. (2008) Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy. J Infect Dis 197:714-20
Cortez, Karoll J; Roilides, Emmanuel; Quiroz-Telles, Flavio et al. (2008) Infections caused by Scedosporium spp. Clin Microbiol Rev 21:157-97
Moir, Susan; Malaspina, Angela; Ho, Jason et al. (2008) Normalization of B cell counts and subpopulations after antiretroviral therapy in chronic HIV disease. J Infect Dis 197:572-9
Tilton, John C; Manion, Maura M; Luskin, Marlise R et al. (2008) Human immunodeficiency virus viremia induces plasmacytoid dendritic cell activation in vivo and diminished alpha interferon production in vitro. J Virol 82:3997-4006
Arthos, James; Cicala, Claudia; Martinelli, Elena et al. (2008) HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells. Nat Immunol 9:301-9
Neumann, Au; Polis, Ma; Rozenberg, L et al. (2007) Differential antiviral effect of PEG-interferon-alpha-2b on HIV and HCV in the treatment of HIV/HCV co-infected patients. AIDS 21:1855-65
Meyers, Jennifer Hartt; Justement, J Shawn; Hallahan, Claire W et al. (2007) Impact of HIV on cell survival and antiviral activity of plasmacytoid dendritic cells. PLoS ONE 2:e458
Malaspina, Angela; Moir, Susan; Chaitt, Doreen G et al. (2007) Idiopathic CD4+ T lymphocytopenia is associated with increases in immature/transitional B cells and serum levels of IL-7. Blood 109:2086-8
Kottilil, Shyam; Jackson, Julia O; Reitano, Kristin N et al. (2007) Innate immunity in HIV infection: enhanced susceptibility to CD95-mediated natural killer cell death and turnover induced by HIV viremia. J Acquir Immune Defic Syndr 46:151-9

Showing the most recent 10 out of 28 publications