Gene and Immunotherapy of Neoplams Affecting Human Communication

Van Waes, C.

Abstract

As the foundation for developing strategies for gene and immunotherapy of neoplasms affecting human communication, research has focused on the identification of immune recognition determinants, components of the inflammatory response, and cytokines in the environment of developing squamous cell neoplasms of the upper aerodigestive tract. Immune and in situ reverse transcription-polymerase chain reaction (RT-PCR) histochemistry are being used to define the cell types present in the tumor environment and expression of gene products involved in immunity. Gene transfer of selected cytokines and recognition determinants which may promote protective helper and cytolytic T lymphocyte immunity to squamous cell carcinoma are being tested in experimental tumor models.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Deafness and Other Communication Disorders (NIDCD)
• Type: Intramural Research (Z01)
• Project #: 1Z01DC000016-94
• Application #: 3753174
• Support Year: 94
• Fiscal Year: 1994

Institution

• Name: National Institute on Deafness and Other Communication Disorders
• Country: United States

Publications

Lu, Hai; Yan, Carol; Quan, Xin Xin et al. (2014) CK2 phosphorylates and inhibits TAp73 tumor suppressor function to promote expression of cancer stem cell genes and phenotype in head and neck cancer. Neoplasia 16:789-800

Lu, Hai; Yang, Xinping; Duggal, Praveen et al. (2011) TNF-? promotes c-REL/?Np63? interaction and TAp73 dissociation from key genes that mediate growth arrest and apoptosis in head and neck cancer. Cancer Res 71:6867-77

Su, Liya; Xu, Guihua; Shen, Jie et al. (2010) Anticancer bioactive peptide suppresses human gastric cancer growth through modulation of apoptosis and the cell cycle. Oncol Rep 23:3-9

Wang, Frederick; Arun, Pattatheyil; Friedman, Jay et al. (2009) Current and potential inflammation targeted therapies in head and neck cancer. Curr Opin Pharmacol 9:389-95

Arun, Pattatheyil; Brown, Matthew S; Ehsanian, Reza et al. (2009) Nuclear NF-kappaB p65 phosphorylation at serine 276 by protein kinase A contributes to the malignant phenotype of head and neck cancer. Clin Cancer Res 15:5974-84

Pernas, Francisco G; Allen, Clint T; Winters, Mary E et al. (2009) Proteomic signatures of epidermal growth factor receptor and survival signal pathways correspond to gefitinib sensitivity in head and neck cancer. Clin Cancer Res 15:2361-72

King, Kathryn E; Ponnamperuma, Roshini M; Allen, Clint et al. (2008) The p53 homologue DeltaNp63alpha interacts with the nuclear factor-kappaB pathway to modulate epithelial cell growth. Cancer Res 68:5122-31

Chen, Zhong; Yan, Bin; Van Waes, Carter (2008) The Role of the NF-kappaB Transcriptome and Proteome as Biomarkers in Human Head and Neck Squamous Cell Carcinomas. Biomark Med 2:409-426

Poff, Jason A; Allen, Clint T; Traughber, Bryan et al. (2008) Pulsed high-intensity focused ultrasound enhances apoptosis and growth inhibition of squamous cell carcinoma xenografts with proteasome inhibitor bortezomib. Radiology 248:485-91

Allen, Clint; Saigal, Kunal; Nottingham, Liesl et al. (2008) Bortezomib-induced apoptosis with limited clinical response is accompanied by inhibition of canonical but not alternative nuclear factor-{kappa}B subunits in head and neck cancer. Clin Cancer Res 14:4175-85