We have completed RAGE dimerization/oligomerization studies and a manuscript has been published. We continue to collaborate with colleagues in Australia to study RAGE thiol-disulfide bond exchange on the cell surface. Proteomics data showed that RAGE is acetylated. We are working with Johns Hopkins colleagues to study how such modification impact RAGE signaling and/or biology. We currently have engineered a tripartite split GFP-based system to identify RAGE signaling partner(s) in the cell. The work is making progress.
|Peng, Yunqian; Kim, Ji-Min; Park, Hal-Sol et al. (2016) AGE-RAGE signal generates a specific NF-ÎºB RelA "barcode" that directs collagen I expression. Sci Rep 6:18822|
|Low, Daren; Subramaniam, Renuka; Lin, Li et al. (2015) Chitinase 3-like 1 induces survival and proliferation of intestinal epithelial cells during chronic inflammation and colitis-associated cancer by regulating S100A9. Oncotarget 6:36535-50|
|Wei, Wen; Lampe, Leonie; Park, Sungha et al. (2012) Disulfide bonds within the C2 domain of RAGE play key roles in its dimerization and biogenesis. PLoS One 7:e50736|