Understanding the performance of the left ventricle requires not only examining the properties of the left ventricle itself, but also investigating the modulating effects of the arterial system on left ventricular (LV) performance. The interaction of the left ventricle with the arterial system, termed arterial-ventricular coupling, is a central determinant of cardiovascular performance and cardiac energetics. Arterial-ventricular coupling (EA/ELV) can be indexed by the ratio of effective arterial elastance (EA;a measure of the net arterial load exerted on the left ventricle) to LV end-systolic elastance (ELV;a load independent measure of LV chamber performance). At rest, in healthy individuals, EA/ELV is maintained within a narrow range, which allows the cardiovascular system to optimize energetic efficiency at the expense of mechanical efficacy. During exercise, an acute mismatch between the arterial and ventricular systems occurs, due to a disproportionate increase in ELV (from an average of 4.3 to 13.2, and 4.7 to 15.5 mmHg/ml/m(1) in men and women, respectively) vs. EA (from an average of 2.3 to 3.2, and 2.3 to 2.9 mmHg/ml/m(1) in men and women, respectively), to ensure that sufficient cardiac performance is achieved to meet the increased energetic requirements of the body. As a result EA/ELV decreases from an average of 0.58 to 0.34, and 0.52 to 0.27 in men and women, respectively. However, with advancing age the reduction in EA/ELV from rest to peak exercise is blunted in older men and women, because of a deficit in the ability to augment ELV during exercise (1). Sodium nitroprusside is a clinically available vasodilating agent that is primarily used in patients with congestive heart failure or with hypertensive crises. Sodium nitroprusside is considered a balanced vasodilator, because, at rest, it lowers LV preload by increasing venous capacitance, and it lowers arterial afterload predominantly by decreasing peripheral vascular resistance. In the heart, sodium nitroprusside enhances LV relaxation through a cGMP-mediated pathway, and it can also increase contractility through a cGMP-independent pathway. We evaluated the effects of sodium nitroprusside on EA/ELV and its components at rest and during graded exercise. Sodium nitroprusside and saline placebo were administered to 15 older (70+/-8years) and 9 younger (31+/-4years) healthy subjects on separate days. EA/ELV was non-invasively characterized as end-systolic volume (ESV)/stroke volume(SV), EA=end-systolic pressure (ESP)/SV, and ELV=ESP/ESV. At rest, in the older and younger groups, sodium nitroprusside respectively lowered EA by 10% (p<0.05) and 4% (p=NS), increased ELV by 47% and 27% (p<0.01), and thus reduced EA/ELV by 31% and 27% (p<0.01) compared to placebo. At peak exercise, sodium nitroprusside did not significantly influence EA in either age group. However, sodium nitroprusside increased ELV by 68% (p<0.01) and 46% (p<0.07) in the older and younger groups respectively, and thus reduced EA/ELV by 36% and 22% (p<0.001) compared to placebo. Importantly, the age-associated deficit in EA/ELV during exercise was attenuated by sodium nitroprusside. Thus, examining EA/ELV and its components can provide useful mechanistic insights into cardiovascular performance both at rest and during exercise (1). Sodium nitroprusside attenuated the age-associated deficits in peak EA/ELV, indicating that some of the age-associated deficits in cardiovascular performance during exercise are acutely reversible. The arterial system is increasingly recognized as an important modulator of cardiac performance, and a potent predictor of cardiovascular (CV) outcomes. The arterial system imposes a load on the heart, both at rest and during exercise. A higher arterial load increases the stroke work required to eject a given amount of blood, and thus increases the hearts energetic costs. Although it is known that a higher arterial load at rest has important effects on CV performance and CV disease, the effects of a change in arterial load on CV performance is unknown. We therefore examined the changes in arterial elastance (EAI) during exercise, and investigate whether these changes are associated with patterns of changes in the arterial and cardiac responses to exercise. 352 subjects (22-93 years) without cardiac disease underwent rest and exercise gated blood pool scans to measure cardiac volumes and derive EAI end systolic pressure/stroke volume index(SVI), PVRI mean BP/(SVI*HR), and TACI (SVI/pulse pressure). We found that the change from rest to peak exercise in EAI (deltaEAI) was heterogeneous (range -44% to 149%), indicating that some individuals decreased their arterial load, whereas others had a large increase in arterial load during exercise. Independent of age, sex and maximal workload, deltaEAI was directly correlated with deltaHR (r=0.12, p<0.05) and deltaPVRI (r=0.41, P<0.01), and inversely associated with deltaTACI (r=-0.46, p<0.01). deltaPVRI and deltaTACI were inversely related to each other (r=-0.17, p<0.01). deltaEAI was also inversely correlated with deltaEDVI (r=-0.58, p<0.01), deltaSVI (r=-0.68, p<0.01) and deltaCI (r=-0.37, p<0.01). Similarly, deltaPVRI was inversely related to deltaEDVI, deltaSVI and deltaCI, whereas deltaTACI was directly associated with these cardiac variables. In conclusion we found that in healthy individuals the changes in EAI during exercise are determined by distinct patterns of changes in arterial properties that are coupled to specific patterns of changes in cardiac parameters. These findings suggest a cross-talk among large and small vessels and cardiac volumes and function, and provide novel insights into the dynamic cardiovascular alterations during exercise. Longitudinal measurements of the MUGA at rest and during exercise have been completed and analyses are now underway. The database will include 106 men and 57 women who had two MUGA scans on average 13 years apart.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG000802-19
Application #
8156787
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
19
Fiscal Year
2010
Total Cost
$73,995
Indirect Cost
Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
Zip Code
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