InCHIANTI is being performed in two sites: Greve in Chianti (Site 1;11,709 inhabitants;19.3% >65 years;located in the middle of a rural area) and Bagno a Ripoli (Village of Antella, site 2, 4704 inhabitants;20.3% >65 years;located immediately adjacent to the urban area of Florence). To obtain two representative samples of the population, the same two stage sampling procedure was used in each of the two sites. For the baseline cohort, in August 1998, a random sample of 1270 persons aged 65 years or older was randomly selected from the population registry of the two sites. Another 29 subjects were randomly selected among those who were 90 years old or older, until at least 30 men and 30 women from this age group were included in the sample. Finally, men and women randomly sampled from the age strata 20-29, 30-39, 40-49, 50-59, and 60-64 years were sequentially invited to participate in the study, until at least 30 men and 30 women for each decade from 20 to 59, and 15 men and 15 women aged 60 to 64 had been enrolled. An overarching hypothesis of the study is that most persons with walking disabilities have limitations in one or more of six physiologic subsystems and that the clinical evaluation of these subsystems can be valuable in planning both treatment and preventive interventions. These subsystems include: 1) Bones and joints;2) Muscles;3) Central nervous system;4) Peripheral nervous system;5) Perceptual system;and 6) Energy production and delivery. In addition to the clinical assessments done during the examination a large library of biological measures have been accumulated through NIA funding and collaborations with outside investigators. The InChianti Study cohorts were assessed at baseline in 1998-2000, 3 years later, in 2001-2003, 6 years later, in 2004-2006, 9 years later, in 2007-2009, and are currently being examined (2013) for a fourth round of follow-up, at both sites, funded by the Tuscany Region Government. There are still approximately 750 subjects still alive, and the response rate is approximately 78%. Follow-up examinations repeat most elements of the baseline evaluation.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG001050-06
Application #
8736684
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2013
Total Cost
$91,257
Indirect Cost
Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
Zip Code
Fabbri, Elisa; An, Yang; Zoli, Marco et al. (2015) Aging and the burden of multimorbidity: associations with inflammatory and anabolic hormonal biomarkers. J Gerontol A Biol Sci Med Sci 70:63-70
Scuteri, Angelo; Cunha, Pedro G; Rosei, E Agabiti et al. (2014) Arterial stiffness and influences of the metabolic syndrome: a cross-countries study. Atherosclerosis 233:654-60
Chiles, Nancy S; Phillips, Caroline L; Volpato, Stefano et al. (2014) Diabetes, peripheral neuropathy, and lower-extremity function. J Diabetes Complications 28:91-5
Milaneschi, Yuri; Sutin, Angelina R; Terracciano, Antonio et al. (2014) The association between leptin and depressive symptoms is modulated by abdominal adiposity. Psychoneuroendocrinology 42:1-10
Deshpande, Nandini; Metter, Jeffrey E; Guralnik, Jack et al. (2014) Sensorimotor and psychosocial determinants of 3-year incident mobility disability in middle-aged and older adults. Age Ageing 43:64-9
Morrisette-Thomas, Vincent; Cohen, Alan A; Fulop, Tamas et al. (2014) Inflamm-aging does not simply reflect increases in pro-inflammatory markers. Mech Ageing Dev 139:49-57
Zuliani, Giovanni; Morieri, Mario Luca; Volpato, Stefano et al. (2014) Insulin resistance and systemic inflammation, but not metabolic syndrome phenotype, predict 9 years mortality in older adults. Atherosclerosis 235:538-45
Aslibekyan, Stella; Dashti, Hassan S; Tanaka, Toshiko et al. (2014) PRKCZ methylation is associated with sunlight exposure in a North American but not a Mediterranean population. Chronobiol Int 31:1034-40
Maggio, Marcello; Lauretani, Fulvio; De Vita, Francesca et al. (2014) Multiple hormonal dysregulation as determinant of low physical performance and mobility in older persons. Curr Pharm Des 20:3119-48
Ferrucci, L; Baroni, M; Ranchelli, A et al. (2014) Interaction between bone and muscle in older persons with mobility limitations. Curr Pharm Des 20:3178-97

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