The Health, Aging, and Body Composition Study (Health ABC) is a longitudinal cohort of 3,075 men and women, aged 70-79 at baseline in 1997-98, and includes 552 African American men and 729 African American women. At baseline, all cohort members reported no difficulty walking 1/4 mile or up ten steps. The study sites are Memphis, Tennessee and Pittsburgh, Pennsylvania. The study was designed to investigate how changes in body composition (muscle, fat, and bone) act as a common pathway through which weight-related health conditions and behavioral factors contribute to loss of function. Race and gender differences and similarities over the 15 years of the study have been key to understanding health trajectories as the cohort has aged. The study measurements include weight-related health conditions such as diabetes and metabolic disorders, osteoporosis, osteoarthritis of the knee, cardiovascular disease, pulmonary disease, and depression. Body composition was repeatedly measured with both dual energy x-ray absorptiometry and computerized tomography. We also assessed muscle strength, and physical function, as well as an extensive set of biomarkers. The major outcome of the study is persistent difficulty walking 1/4 mile or stair climbing reported over a 6-month period. Other outcomes include cardiovascular events, cancers, fractures, dementia, diabetes, hospitalizations, and deaths. The study has completed 15 years of follow-up through clinical exams and telephone follow-up interviews. Numerous grant-funded ancillary studies have been added by extramural investigators to enhance the interdisciplinary contribution of Health ABC to the research community.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG007390-07
Application #
8552553
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2012
Total Cost
$322,023
Indirect Cost
Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
Zip Code
Contrera, Kevin J; Betz, Josh; Deal, Jennifer et al. (2017) Association of Hearing Impairment and Anxiety in Older Adults. J Aging Health 29:172-184
Rosso, Andrea L; Verghese, Joe; Metti, Andrea L et al. (2017) Slowing gait and risk for cognitive impairment: The hippocampus as a shared neural substrate. Neurology 89:336-342
Santanasto, Adam J; Goodpaster, Bret H; Kritchevsky, Stephen B et al. (2017) Body Composition Remodeling and Mortality: The Health Aging and Body Composition Study. J Gerontol A Biol Sci Med Sci 72:513-519
Houston, Denise K; Tooze, Janet A; Garcia, Katelyn et al. (2017) Protein Intake and Mobility Limitation in Community-Dwelling Older Adults: the Health ABC Study. J Am Geriatr Soc 65:1705-1711
Dong, Jing; Pinto, Jayant M; Guo, Xuguang et al. (2017) The Prevalence of Anosmia and Associated Factors Among U.S. Black and White Older Adults. J Gerontol A Biol Sci Med Sci :
Cooper, Rachel; Huang, Lei; Hardy, Rebecca et al. (2017) Obesity History and Daily Patterns of Physical Activity at Age 60-64 Years: Findings From the MRC National Survey of Health and Development. J Gerontol A Biol Sci Med Sci 72:1424-1430
Marques, Elisa A; Figueiredo, Pedro; Harris, Tamara B et al. (2017) Are resistance and aerobic exercise training equally effective at improving knee muscle strength and balance in older women? Arch Gerontol Geriatr 68:106-112
Cruz-Almeida, Yenisel; Rosso, Andrea; Marcum, Zachary et al. (2017) Associations of Musculoskeletal Pain With Mobility in Older Adults: Potential Cerebral Mechanisms. J Gerontol A Biol Sci Med Sci 72:1270-1276
Garimella, Pranav S; Katz, Ronit; Ix, Joachim H et al. (2017) Association of urinary uromodulin with kidney function decline and mortality: the health ABC study?. Clin Nephrol 87:278-286
Georgiopoulou, Vasiliki V; Kalogeropoulos, Andreas P; Chowdhury, Ritam et al. (2017) Exercise Capacity, Heart Failure Risk, and Mortality in Older Adults: The Health ABC Study. Am J Prev Med 52:144-153

Showing the most recent 10 out of 152 publications