Accomplishments during the year: 1. We continue the search for new receptors through genome-wide analysis of viable merozoites. 2. The immune response to AMA1, RON2 and EBA-175 has been studied. This work continues to expand our understanding of parasite invasion of red cells by identifying the receptors and ligands and determining the potential of these targets for vaccine development. 3. Study of epigenetics, using knockouts of P. falciparum genes involved in histone modification. 4. Antibodies to domains of PfEMP1 in severe disease in children in Africa. 5. Continue to study the cytoplasmic domains of molecules in the moving junction to determine if they bind to aldolase or other molecules that bind actin. Studying viable merozoites during invasion to follow the moving junction. 6. Elucidation of molecular mechanism of junction formation. 7. Plasmodium development in the mosquito.

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Zip Code
Sherling, Emma S; Knuepfer, Ellen; Brzostowski, Joseph A et al. (2017) The Plasmodium falciparum rhoptry protein RhopH3 plays essential roles in host cell invasion and nutrient uptake. Elife 6:
Bansal, Abhisheka; Ojo, Kayode K; Mu, Jianbing et al. (2016) Reduced Activity of Mutant Calcium-Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G. MBio 7:
Cheng, Yang; Lu, Feng; Wang, Bo et al. (2016) Plasmodium vivax GPI-anchored micronemal antigen (PvGAMA) binds human erythrocytes independent of Duffy antigen status. Sci Rep 6:35581
Gunalan, Karthigayan; Lo, Eugenia; Hostetler, Jessica B et al. (2016) Role of Plasmodium vivax Duffy-binding protein 1 in invasion of Duffy-null Africans. Proc Natl Acad Sci U S A 113:6271-6
Draper, Simon J; Angov, Evelina; Horii, Toshihiro et al. (2015) Recent advances in recombinant protein-based malaria vaccines. Vaccine 33:7433-43
Gordon, Emile B; Hart, Geoffrey T; Tran, Tuan M et al. (2015) Targeting glutamine metabolism rescues mice from late-stage cerebral malaria. Proc Natl Acad Sci U S A 112:13075-80
Crompton, Peter D; Moebius, Jacqueline; Portugal, Silvia et al. (2014) Malaria immunity in man and mosquito: insights into unsolved mysteries of a deadly infectious disease. Annu Rev Immunol 32:157-87
Srinivasan, Prakash; Ekanem, Emmanuel; Diouf, Ababacar et al. (2014) Immunization with a functional protein complex required for erythrocyte invasion protects against lethal malaria. Proc Natl Acad Sci U S A 111:10311-6
Desai, Sanjay A; Miller, Louis H (2014) Malaria: Protein-export pathway illuminated. Nature 511:541-2
Miller, Louis H; Ackerman, Hans C; Su, Xin-zhuan et al. (2013) Malaria biology and disease pathogenesis: insights for new treatments. Nat Med 19:156-67

Showing the most recent 10 out of 65 publications