To understand better the pathogenesis of filarial infections (onchocerciasis, loiaisis, lymphatic filarasis) clinical assessments of patients with these and other related non-filarial (strongyloides, malaria) infections have been studied in detail. The influence that filarial infections have on the clinical expression of non-filarial infectious diseases have also been studied by performing clinical trials in filarial-endemic regions of the world that are co-endemic for malaria (Mali), tuberculosis (India) and HIV (India). New diagnostic approaches have been developed and utilized for the rapid and specific diagnosis of Strongyloidiasis, loiasis, and onchocerciasis. Rapid (almost point of care) diagnostics have been developed for surveillance of W. bancrofti and O. volvulus following mass drug distribution campaigns. A potential vaccine candidate for S. stercoralis has been identified.

Project Start
Project End
Budget Start
Budget End
Support Year
28
Fiscal Year
2012
Total Cost
$631,464
Indirect Cost
City
State
Country
Zip Code
Herrick, Jesica A; Legrand, Fanny; Gounoue, Raceline et al. (2017) Posttreatment Reactions After Single-Dose Diethylcarbamazine or Ivermectin in Subjects With Loa loa Infection. Clin Infect Dis 64:1017-1025
Arnold, Benjamin F; van der Laan, Mark J; Hubbard, Alan E et al. (2017) Measuring changes in transmission of neglected tropical diseases, malaria, and enteric pathogens from quantitative antibody levels. PLoS Negl Trop Dis 11:e0005616
Easton, Alice V; Oliveira, Rita G; Walker, Martin et al. (2017) Sources of variability in the measurement of Ascaris lumbricoides infection intensity by Kato-Katz and qPCR. Parasit Vectors 10:256
Priest, David H; Nutman, Thomas B (2017) Loiasis in US Traveler Returning from Bioko Island, Equatorial Guinea, 2016. Emerg Infect Dis 23:160-162
Johnson, Tory; Nutman, Thomas; Dowell, Scott et al. (2017) Closing the Loop between Nodding Syndrome and Onchocerca Infection. Trends Parasitol 33:490
Johnson, Tory P; Tyagi, Richa; Lee, Paul R et al. (2017) Nodding syndrome may be an autoimmune reaction to the parasitic worm Onchocerca volvulus. Sci Transl Med 9:
Nutman, Thomas B (2017) Human infection with Strongyloides stercoralis and other related Strongyloides species. Parasitology 144:263-273
Pedram, Bijan; Pasquetto, Valérie; Drame, Papa M et al. (2017) A novel rapid test for detecting antibody responses to Loa loa infections. PLoS Negl Trop Dis 11:e0005741
Pion, Sébastien D; Montavon, Céline; Chesnais, Cédric B et al. (2016) Positivity of Antigen Tests Used for Diagnosis of Lymphatic Filariasis in Individuals Without Wuchereria bancrofti Infection But with High Loa loa Microfilaremia. Am J Trop Med Hyg 95:1417-1423
O'Connell, Elise M; Nutman, Thomas B (2016) Molecular Diagnostics for Soil-Transmitted Helminths. Am J Trop Med Hyg 95:508-13

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