Abstract

In FY 2015, we continued our investigation of virulence factors that contribute to Staphylococcus aureus pathogenesis and immune evasion. The focus is on understanding which factors define the virulence potential of highly virulent MSSA and MRSA clones, in particular of community-associated MRSA. For example, we analyzed the virulence factors contributing to an emerging, highly virulent MSSA clone that caused several cases of fatal pneumonia in Brazil. Furthermore, we continued our close and fruitful collaboration with Dr. Min Li in Shanghai, analyzing several virulence factors of CA-MRSA and hospital-associated MRSA clones that are predominant in China. Finally, we continue our mechanistic studies on phenol-soluble modulins, peptide toxins of S. aureus identified in our laboratory.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAI000904-15
Application #
9354770
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
15
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
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  Publications

Zheng, Yue; He, Lei; Asiamah, Titus K et al. (2018) Colonization of medical devices by staphylococci. Environ Microbiol 20:3141-3153
He, Lei; Zheng, Hong-Xiang; Wang, Yanan et al. (2018) Detection and analysis of methicillin-resistant human-adapted sequence type 398 allows insight into community-associated methicillin-resistant Staphylococcus aureus evolution. Genome Med 10:5
Fisher, Emilie L; Otto, Michael; Cheung, Gordon Y C (2018) Basis of Virulence in Enterotoxin-Mediated Staphylococcal Food Poisoning. Front Microbiol 9:436
Jones, Dennis; Meijer, Eelco F J; Blatter, Cedric et al. (2018) Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction. Sci Transl Med 10:
Schlatterer, Katja; Beck, Christian; Hanzelmann, Dennis et al. (2018) The Mechanism behind Bacterial Lipoprotein Release: Phenol-Soluble Modulins Mediate Toll-Like Receptor 2 Activation via Extracellular Vesicle Release from Staphylococcus aureus. MBio 9:
Nakatsuji, Teruaki; Chen, Tiffany H; Butcher, Anna M et al. (2018) A commensal strain of Staphylococcus epidermidis protects against skin neoplasia. Sci Adv 4:eaao4502
Zheng, Yue; Joo, Hwang-Soo; Nair, Vinod et al. (2018) Do amyloid structures formed by Staphylococcus aureus phenol-soluble modulins have a biological function? Int J Med Microbiol 308:675-682
Cheung, Gordon Y C; Fisher, Emilie L; McCausland, Joshua W et al. (2018) Antimicrobial Peptide Resistance Mechanism Contributes to Staphylococcus aureus Infection. J Infect Dis 217:1153-1159
Blake, Kimbria J; Baral, Pankaj; Voisin, Tiphaine et al. (2018) Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314. Nat Commun 9:37
Piewngam, Pipat; Zheng, Yue; Nguyen, Thuan H et al. (2018) Pathogen elimination by probiotic Bacillus via signalling interference. Nature 562:532-537

Showing the most recent 10 out of 119 publications