Research in this project is currently focused on three areas. These are characterization of the survivors of the anthrax attacks of 2001;characterization of emerging respiratory infections including SARS and influenza;and development of novel therapies for flu. The anthrax study has enrolled a cohort of volunteers who are currently undergoing an extensive diagnostic evaluation. To be ready to deal with emerging infectious diseases of the respiratory tract, a protocol has been developed to systematically study patients presenting with a compatible symptom complex. This protocol has been complemented by the development of treatment protocols that will utilize hyperimmune plasma to the 2009 H1N1 virus or a combination of antiviral chemotherapeutic agents.

Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
2012
Total Cost
$171,956
Indirect Cost
City
State
Country
Zip Code
Davey Jr, Richard T; Dodd, Lori; Proschan, Michael et al. (2018) The Past Need Not Be Prologue: Recommendations for Testing and Positioning the Most-Promising Medical Countermeasures for the Next Outbreak of Ebola Virus Infection. J Infect Dis :
Beigel, John H; Tebas, Pablo; Elie-Turenne, Marie-Carmelle et al. (2017) Immune plasma for the treatment of severe influenza: an open-label, multicentre, phase 2 randomised study. Lancet Respir Med 5:500-511
Kennedy, Stephen B; Bolay, Fatorma; Kieh, Mark et al. (2017) Phase 2 Placebo-Controlled Trial of Two Vaccines to Prevent Ebola in Liberia. N Engl J Med 377:1438-1447
Regules, Jason A; Beigel, John H; Paolino, Kristopher M et al. (2017) A Recombinant Vesicular Stomatitis Virus Ebola Vaccine. N Engl J Med 376:330-341
Beigel, John H; Bao, Yajing; Beeler, Joy et al. (2017) Oseltamivir, amantadine, and ribavirin combination antiviral therapy versus oseltamivir monotherapy for the treatment of influenza: a multicentre, double-blind, randomised phase 2 trial. Lancet Infect Dis 17:1255-1265
Dodd, Lori E; Proschan, Michael A; Neuhaus, Jacqueline et al. (2016) Design of a Randomized Controlled Trial for Ebola Virus Disease Medical Countermeasures: PREVAIL II, the Ebola MCM Study. J Infect Dis 213:1906-13
Chertow, Daniel S; Nath, Avindra; Suffredini, Anthony F et al. (2016) Severe Meningoencephalitis in a Case of Ebola Virus Disease: A Case Report. Ann Intern Med 165:301-4
Lane, H Clifford; Marston, Hilary D; Fauci, Anthony S (2016) Conducting clinical trials in outbreak settings: Points to consider. Clin Trials 13:92-5
Kennedy, Stephen B; Neaton, James D; Lane, H Clifford et al. (2016) Implementation of an Ebola virus disease vaccine clinical trial during the Ebola epidemic in Liberia: Design, procedures, and challenges. Clin Trials 13:49-56
Liddell, Allison M; Davey Jr, Richard T; Mehta, Aneesh K et al. (2015) Characteristics and Clinical Management of a Cluster of 3 Patients With Ebola Virus Disease, Including the First Domestically Acquired Cases in the United States. Ann Intern Med 163:81-90

Showing the most recent 10 out of 18 publications