We are interested in how bacteria and bacterial products shape the development of subsequent innate and adaptive immune responses with the goal of understanding how these host-microbe interactions influence pathogenesis of infections, autoimmunity, allergy, and cancer. In particular, we have focused on the role of interleukin (IL)-17 and related cytokines in mucosal host defense. In 2012, we have investigated host immune responses against pathogens at the skin (Staphylococcus aureus), lung (Cryptococcus), and gut (Citrobacter). These studies have resulted in insights into the regulation of IL-17-related cytokines and their role in protection against these infections. With these studies we have enhanced our understanding of the mechanisms controlling mucosal T cell differentiation and identified potential pathways that can be targeted to enhance efficacy of vaccines and therapies against cancer, infectious, and immune-mediated diseases.

Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2012
Total Cost
$1,035,686
Indirect Cost
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State
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Sastalla, Inka; Williams, Kelli W; Anderson, Erik D et al. (2017) Molecular Typing of Staphylococcus aureus Isolated from Patients with Autosomal Dominant Hyper IgE Syndrome. Pathogens 6:
Gough, Portia; Ganesan, Sundar; Datta, Sandip K (2017) IL-20 Signaling in Activated Human Neutrophils Inhibits Neutrophil Migration and Function. J Immunol 198:4373-4382
Karauzum, Hatice; Haudenschild, Christian C; Moore, Ian N et al. (2017) Lethal CD4 T Cell Responses Induced by Vaccination Against Staphylococcus aureus Bacteremia. J Infect Dis 215:1231-1239
Myles, Ian A; Zhao, Ming; Nardone, Glenn et al. (2016) CD8+ T cells produce a dialyzable antigen-specific activator of dendritic cells. J Leukoc Biol :
Myles, Ian A; Williams, Kelli W; Reckhow, Jensen D et al. (2016) Transplantation of human skin microbiota in models of atopic dermatitis. JCI Insight 1:
Myles, Ian A; Reckhow, Jensen D; Williams, Kelli W et al. (2016) A method for culturing Gram-negative skin microbiota. BMC Microbiol 16:60
Pincus, Nathan B; Reckhow, Jensen D; Saleem, Danial et al. (2015) Strain Specific Phage Treatment for Staphylococcus aureus Infection Is Influenced by Host Immunity and Site of Infection. PLoS One 10:e0124280
Sastalla, Inka; Datta, Sandip K (2015) Antibiotic Education: Not Just Another Brick in the Cell Wall. Cell Host Microbe 18:520-2
Drummond, Rebecca A; Collar, Amanda L; Swamydas, Muthulekha et al. (2015) CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System. PLoS Pathog 11:e1005293
Myles, Ian A; Pincus, Nathan B; Fontecilla, Natalia M et al. (2014) Effects of parental omega-3 fatty acid intake on offspring microbiome and immunity. PLoS One 9:e87181

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