We are interested in how bacteria and bacterial products shape the development of subsequent innate and adaptive immune responses with the goal of understanding how these host-microbe interactions influence pathogenesis of infections, autoimmunity, allergy, and cancer. In 2013, we have focused on host defense against the bacterial pathogen Staphylococcus aureus. These studies have uncovered the role of the IL-20 receptor in promoting S. aureus skin infection, providing insight into the regulation of key anti-staphylococcal inflammatory pathways such as IL-1 and IL-17 during infection. In addition, in 2013 we have identified the role of dietary exposures and host responses to intestinal commensals on development of IL-17-related immune responses that are relevant to susceptibility to infection and inflammatory diseases. With these studies we have enhanced our understanding of the mechanisms controlling skin and mucosal host defense and identified potential pathways that can be targeted to enhance efficacy of vaccines and therapies against cancer, infection, and immune-mediated diseases.

Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2013
Total Cost
$882,903
Indirect Cost
City
State
Country
Zip Code
Myles, Ian A; Williams, Kelli W; Reckhow, Jensen D et al. (2016) Transplantation of human skin microbiota in models of atopic dermatitis. JCI Insight 1:
Myles, Ian A; Reckhow, Jensen D; Williams, Kelli W et al. (2016) A method for culturing Gram-negative skin microbiota. BMC Microbiol 16:60
Karauzum, Hatice; Datta, Sandip K (2016) Adaptive Immunity Against Staphylococcus aureus. Curr Top Microbiol Immunol :
Sastalla, Inka; Datta, Sandip K (2015) Antibiotic Education: Not Just Another Brick in the Cell Wall. Cell Host Microbe 18:520-2
Drummond, Rebecca A; Collar, Amanda L; Swamydas, Muthulekha et al. (2015) CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System. PLoS Pathog 11:e1005293
Pincus, Nathan B; Reckhow, Jensen D; Saleem, Danial et al. (2015) Strain Specific Phage Treatment for Staphylococcus aureus Infection Is Influenced by Host Immunity and Site of Infection. PLoS One 10:e0124280
Hanson, Miranda L; Hixon, Julie A; Li, Wenqing et al. (2014) Oral delivery of IL-27 recombinant bacteria attenuates immune colitis in mice. Gastroenterology 146:210-221.e13
Janelsins, Brian M; Lu, Mingfang; Datta, Sandip K (2014) Altered inactivation of commensal LPS due to acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 immunity. Proc Natl Acad Sci U S A 111:373-8
Myles, Ian A; Pincus, Nathan B; Fontecilla, Natalia M et al. (2014) Effects of parental omega-3 fatty acid intake on offspring microbiome and immunity. PLoS One 9:e87181
Myles, Ian A; Fontecilla, Natalia M; Valdez, Patricia A et al. (2013) Signaling via the IL-20 receptor inhibits cutaneous production of IL-1ýý and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus. Nat Immunol 14:804-11

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