International Research in Thailand

Holland, Steven

Abstract

We have previously identified autoantibodies to interferon gamma in patients in northern Thailand who have disseminated nontuberculous mycobacterial infections. We have also shown that blood bank donors do not have these autoantibodies. This last year we have passed the protocol and developed the infrastructure in Thailand to execute this project. In addition, we have identified sites in Taiwan and other sites in Thailand at which these cases are diagnosed. We have confirmed the presence of anti-interferon gamma autoantibodies in multiple subjects from the various sites. We have also identified a population with autoantibodies and thymoma, a form of thymic cancer. We have developed the local laboratory support to obtain appropriate lymphocyte counts and plasma samples and cytokine stimulations for shipment to the NIH for analysis.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Investigator-Initiated Intramural Research Projects (ZIA)
• Project #: 1ZIAAI001069-02
• Application #: 7964706
• Support Year: 2
• Fiscal Year: 2009
• Total Cost: $126,863

Institution

• Name: National Institute of Allergy and Infectious Diseases

Publications

Holland, Steven M; Pierce, Virginia M; Shailam, Randheer et al. (2017) Case 28-2017. A 13-Month-Old Girl with Pneumonia and a 33-Year-Old Woman with Hip Pain. N Engl J Med 377:1077-1091

Marciano, Beatriz E; Holland, Steven M (2017) Primary Immunodeficiency Diseases: Current and Emerging Therapeutics. Front Immunol 8:937

Crum-Cianflone, Nancy F; Lam, Pamela V; Ross-Walker, Sarah et al. (2017) Autoantibodies to Granulocyte-Macrophage Colony-Stimulating Factor Associated With Severe and Unusual Manifestations of Cryptococcus gattii Infections. Open Forum Infect Dis 4:ofx211

Ku, Cheng-Lung; Lin, Chia-Hao; Chang, Su-Wei et al. (2016) Anti-IFN-? autoantibodies are strongly associated with HLA-DR*15:02/16:02 and HLA-DQ*05:01/05:02 across Southeast Asia. J Allergy Clin Immunol 137:945-8.e8

Xie, Yingda L; Chen, Ray Y; Sereti, Irini et al. (2016) Reply to Tham et al. Clin Infect Dis 63:573-4

Xie, Yingda L; Rosen, Lindsey B; Sereti, Irini et al. (2016) Severe Paradoxical Reaction During Treatment of Disseminated Tuberculosis in a Patient With Neutralizing Anti-IFN? Autoantibodies. Clin Infect Dis 62:770-773

Wu, Un-In; Holland, Steven M (2016) A genetic perspective on granulomatous diseases with an emphasis on mycobacterial infections. Semin Immunopathol 38:199-212

Szymanski, Eva P; Leung, Janice M; Fowler, Cedar J et al. (2015) Pulmonary Nontuberculous Mycobacterial Infection. A Multisystem, Multigenic Disease. Am J Respir Crit Care Med 192:618-28

Burbelo, Peter D; Keller, Jason; Wagner, Jason et al. (2015) Serological diagnosis of pulmonary Mycobacterium tuberculosis infection by LIPS using a multiple antigen mixture. BMC Microbiol 15:205

Martinez, Bianca; Browne, Sarah K (2014) Good syndrome, bad problem. Front Oncol 4:307