International Research in Thailand

Holland, Steven

Abstract

We have previously identified autoantibodies to interferon gamma in patients in northern Thailand who have disseminated nontuberculous mycobacterial infections. We have also shown that blood bank donors do not have these autoantibodies. This last year we have developed the infrastructure in Thailand and Taiwan to execute this project and then completed our entire enrollment in 6 months. All samples are now in Bethesda for anticytokine autoantibody testing. We have confirmed the presence of anti-interferon gamma autoantibodies in the majority of the disseminated nontuberculous infection subjects from the various sites. In parallel with this project in Thailand, we identified a population of patients with anticytokine autoantibodies and thymoma, a form of thymic cancer. We have developed the local laboratory support to obtain appropriate lymphocyte counts and plasma samples and cytokine stimulations and comprehensive anticytokine autoantibody detection through our collaborator, Dr. Peter Burbelo.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Investigator-Initiated Intramural Research Projects (ZIA)
• Project #: 1ZIAAI001069-03
• Application #: 8157056
• Support Year: 3
• Fiscal Year: 2010
• Total Cost: $55,001

Institution

• Name: National Institute of Allergy and Infectious Diseases

Publications

Holland, Steven M; Pierce, Virginia M; Shailam, Randheer et al. (2017) Case 28-2017. A 13-Month-Old Girl with Pneumonia and a 33-Year-Old Woman with Hip Pain. N Engl J Med 377:1077-1091

Marciano, Beatriz E; Holland, Steven M (2017) Primary Immunodeficiency Diseases: Current and Emerging Therapeutics. Front Immunol 8:937

Crum-Cianflone, Nancy F; Lam, Pamela V; Ross-Walker, Sarah et al. (2017) Autoantibodies to Granulocyte-Macrophage Colony-Stimulating Factor Associated With Severe and Unusual Manifestations of Cryptococcus gattii Infections. Open Forum Infect Dis 4:ofx211

Ku, Cheng-Lung; Lin, Chia-Hao; Chang, Su-Wei et al. (2016) Anti-IFN-? autoantibodies are strongly associated with HLA-DR*15:02/16:02 and HLA-DQ*05:01/05:02 across Southeast Asia. J Allergy Clin Immunol 137:945-8.e8

Xie, Yingda L; Chen, Ray Y; Sereti, Irini et al. (2016) Reply to Tham et al. Clin Infect Dis 63:573-4

Xie, Yingda L; Rosen, Lindsey B; Sereti, Irini et al. (2016) Severe Paradoxical Reaction During Treatment of Disseminated Tuberculosis in a Patient With Neutralizing Anti-IFN? Autoantibodies. Clin Infect Dis 62:770-773

Wu, Un-In; Holland, Steven M (2016) A genetic perspective on granulomatous diseases with an emphasis on mycobacterial infections. Semin Immunopathol 38:199-212

Szymanski, Eva P; Leung, Janice M; Fowler, Cedar J et al. (2015) Pulmonary Nontuberculous Mycobacterial Infection. A Multisystem, Multigenic Disease. Am J Respir Crit Care Med 192:618-28

Burbelo, Peter D; Keller, Jason; Wagner, Jason et al. (2015) Serological diagnosis of pulmonary Mycobacterium tuberculosis infection by LIPS using a multiple antigen mixture. BMC Microbiol 15:205

Martinez, Bianca; Browne, Sarah K (2014) Good syndrome, bad problem. Front Oncol 4:307