Abstract

The PapillomaVirus Episteme (PaVE) has been established to provide information and bioinformatics resources to the scientific community for research on the Papillomaviridae family of viruses. The PaVE consists of a relational database and web applications that support the storage, annotation, analysis, and exchange of information. PAVE can be found at http://pave.niaid.nih.gov PaVe contains genomic and protein sequences for all papillomaviruses. It includes a multiple sequence alignment tool, a protein structure viewer, a viral typing tool and an Image viewer for visualizing clinical manifestations of viral infection. This year we have added a circular genome browser and a phylogenetic tool. Linked review articles provided detailed information about all aspects of functional genomics of papillomaviruses.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAI001071-08
Application #
9161635
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2015
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
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State
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  Publications

Mirabello, Lisa; Clarke, Megan A; Nelson, Chase W et al. (2018) The Intersection of HPV Epidemiology, Genomics and Mechanistic Studies of HPV-Mediated Carcinogenesis. Viruses 10:
Van Doorslaer, Koenraad; Chen, Zigui; Bernard, Hans-Ulrich et al. (2018) ICTV Virus Taxonomy Profile: Papillomaviridae. J Gen Virol 99:989-990
Van Doorslaer, Koenraad; Li, Zhiwen; Xirasagar, Sandhya et al. (2017) The Papillomavirus Episteme: a major update to the papillomavirus sequence database. Nucleic Acids Res 45:D499-D506
Van Doorslaer, Koenraad; McBride, Alison A (2016) Molecular archeological evidence in support of the repeated loss of a papillomavirus gene. Sci Rep 6:33028
Buck, Christopher B; Van Doorslaer, Koenraad; Peretti, Alberto et al. (2016) The Ancient Evolutionary History of Polyomaviruses. PLoS Pathog 12:e1005574
Van Doorslaer, Koenraad; Tan, Qina; Xirasagar, Sandhya et al. (2013) The Papillomavirus Episteme: a central resource for papillomavirus sequence data and analysis. Nucleic Acids Res 41:D571-8
Lambert, Paul F; McBride, Alison; Ulrich Bernard, Hans (2013) Special issue: The Papillomavirus Episteme. Virology :
Van Doorslaer, Koenraad (2013) Evolution of the Papillomaviridae. Virology :
Buck, Christopher B; Phan, Giao Q; Raiji, Manish T et al. (2012) Complete genome sequence of a tenth human polyomavirus. J Virol 86:10887